biostudies-literatureUnknown25(5)GBD 2021 Diarrhoeal Diseases CollaboratorsBill &amp; Melinda Gates Foundation<h4>Background</h4>Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.<h4>Methods</h4>We used the Cause of Death Ensemble modelling strategy to analyse vital registration data, verbal aThe Lancet. Infectious diseases519-536https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018300biostudies-literatureGlobal, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990-2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021.PMC12018300Girmay AAFakhri-Demeshghieh ABeiranvand MNguyen NNYAnwar SJacobsen KHOjo-Akosile TRRodrigues MAlmustanyir SRoudashti SAgide FDAbidi HSarkar TMokdad AHEd-Dra ARoss AGRahman MABender RGKuddus MASahoo SSShanawaz MMulita FAbualruz HJalilzadeh Yengejeh RUdoh ASamadi Kafil HKadir DHHKarami JDohare SMunkhsaikhan YAdhikary RKFakhradiyev IRKabir HGetachew MERashidi MMTalukder AKhalilian ABorhany HGoleij POkeke INSaddik BANaghavi PIslam SMSRonfani LChichagi FYaghoubi SLahariya CPerianayagam AAddo IYAhinkorah BONajmuldeen HHROlufadewa IIOrtega-Altamirano DVShiferaw DBardhan MDsouza HLNaghavi MBalakrishnan SHosseinzadeh MHasan MKQasim NHMishra VLo CHChutiyami 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their risk factors, and aetiologies, 1990-2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021.<h4>Background</h4>Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.<h4>Methods</h4>We used the Cause of Death Ensemble modelling strategy to analyse vital registration data, verbal a2025-01-01T00:00:00Z2025 May2025-06-25T03:06:38.401Z2025-06-25T03:06:38.401ZS-EPMC120183003970882210.1016/S1473-3099(24)00691-1