biostudies-literatureUnknown10(4)Foschi M<h4>Introduction</h4>Patients with ischemic stroke or transient ischemic attack (TIA) and cancer face unique risks of recurrent ischemic events and bleeding. It is unclear whether this increased risk is present even in patients with minor ischemic stroke or transient ischemic attack (TIA) receiving dual antiplatelet therapy (DAPT). This study aimed to evaluate the impact of cancer on the short-term outcomes after DAPT in patients with non-cardioembolic minor ischemic stroke or high-risk TIA.<h4>Patients and methods</h4>This was a secondary analysis of the prospective multicentric READAPT study (NCT05476081), including patients with non-cardioembolic minor ischemic stroke (NIHSS ⩽ 5) or high-risk TIA (ABCD2 ⩾4) who initiated DAPT within 48 h of symptom onset. The primary effectiveness outcoEuropean stroke journal1489-1501https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018360biostudies-literatureEffectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study.PMC12018360D'Anna LAndreone VMuscia FCandelaresi PRicci SRusso MPezzini ARota EMezzapesa DMFerrandi DRinaldi CPassarelli FVinciguerra LCaggia EABongioanni MRCaputi LRinaldi GTassi RSaia VTerruso VMarcon MViticchi GSacco SManobianca GPadiglioni CGuarino MAnticoli SCensori BZedde MLeone RFoschi MSanzaro EDi Blasio FMannino MBarone VMasato MCupini LMFrisullo GFortini ASanna AMosconi MGMastrangelo VTarletti RBeccia MDel Sette MNencini PDe Angelis MVTonon ADe Matteis EDe Michele MTassinari TBonanni LInchingolo VBagnato MRPalmieri CDiamanti SRuzza GDe Boni AInvernizzi PFalcou APistoia FBavaro APuglisi VPaciaroni MCaggiula MPapiri GAcciarri MCZivelonghi CPetruzzellis MZini ACavallini AMOrnello RRomoli MLaspada SScaglione GRoberti CDe Santis FChiti ACenciarelli SDiomedi MOrsucci DBedetti CSepe FNPelliccioni GCappellari MGrisendi IVolpi GPiscaglia MGfalseEffectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study.<h4>Introduction</h4>Patients with ischemic stroke or transient ischemic attack (TIA) and cancer face unique risks of recurrent ischemic events and bleeding. It is unclear whether this increased risk is present even in patients with minor ischemic stroke or transient ischemic attack (TIA) receiving dual antiplatelet therapy (DAPT). This study aimed to evaluate the impact of cancer on the short-term outcomes after DAPT in patients with non-cardioembolic minor ischemic stroke or high-risk TIA.<h4>Patients and methods</h4>This was a secondary analysis of the prospective multicentric READAPT study (NCT05476081), including patients with non-cardioembolic minor ischemic stroke (NIHSS ⩽ 5) or high-risk TIA (ABCD2 ⩾4) who initiated DAPT within 48 h of symptom onset. The primary effectiveness outco2025-01-01T00:00:00Z2025 Dec2026-06-06T07:36:15.009Z2025-07-01T03:05:34.676ZS-EPMC120183604026546310.1177/23969873251333282