{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["105(4)"],"submitter":["Lhotte R"],"pubmed_abstract":["Donor/recipient mismatched HLA antigens can lead to the production of Donor-Specific Antibodies by the recipient, which are deleterious to organ transplants. The HLA-DQ locus is the most frequent target, with both the DQ beta and alpha chains involved. For deceased donors in particular, while HLA-DQB1 has been typed in emergencies for a long time, HLA-DQA1 has only recently been included. No imputation algorithmic tool was available to impute HLA-DQA1 until the development of HaploSFHI, trained on 61,393 two-field typings by NGS methods. We evaluated the accuracy of two-field HLA-DQA1 imputation from serological and two-field level HLA-A, B, DRB1, and DQB1 typings. We report a highly accurate two-field HLA-DQA1 prediction using a French test cohort of 7696 individuals, respectively reachin"],"journal":["HLA"],"pagination":["e70197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018869"],"repository":["biostudies-literature"],"pubmed_title":["Evaluating the Antigen and Eplet Accuracy of DQA1 Imputations With the HaploSFHI Two-Field HLA Typing Inference Tool."],"pmcid":["PMC12018869"],"pubmed_authors":["Lhotte R","Gatouillat G","Tafulo S","Toutirais O","Francois DF","Moalic V","Walencik A","Guillaume N","Basire A","Turner D","Dautin G","Dubois V","Dormoy A","Marie-Joelle A","SFHI Consortium","Usureau C","Aarnink A","Croisille L","Delbos F","Top-Raymond I","Congy N","Jollet I","Taupin JL","Filloux M","Rouzaire PO","Murphey C","Pedron B","Guidicelli LG","Bernard G","Devriese M","Bardy B","Letort V","Proust B"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating the Antigen and Eplet Accuracy of DQA1 Imputations With the HaploSFHI Two-Field HLA Typing Inference Tool.","description":"Donor/recipient mismatched HLA antigens can lead to the production of Donor-Specific Antibodies by the recipient, which are deleterious to organ transplants. The HLA-DQ locus is the most frequent target, with both the DQ beta and alpha chains involved. For deceased donors in particular, while HLA-DQB1 has been typed in emergencies for a long time, HLA-DQA1 has only recently been included. No imputation algorithmic tool was available to impute HLA-DQA1 until the development of HaploSFHI, trained on 61,393 two-field typings by NGS methods. We evaluated the accuracy of two-field HLA-DQA1 imputation from serological and two-field level HLA-A, B, DRB1, and DQB1 typings. We report a highly accurate two-field HLA-DQA1 prediction using a French test cohort of 7696 individuals, respectively reachin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:56.295Z","creation":"2025-07-10T03:08:56.295Z"},"accession":"S-EPMC12018869","cross_references":{"pubmed":["40269614"],"doi":["10.1111/tan.70197"]}}