{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(5)"],"submitter":["Watanabe A"],"pubmed_abstract":["<h4>Background</h4>Evidence is limited regarding the comparative effectiveness and safety of mechanical thrombectomy (MT) vs catheter-directed thrombolysis (CDT) for high-risk pulmonary embolism (PE).<h4>Objectives</h4>This observational study aimed to compare the outcomes of older adults with high-risk PE treated with MT vs CDT using a target trial emulation framework.<h4>Methods</h4>We included Medicare fee-for-service beneficiaries aged 65 to 99 years admitted with high-risk PE (defined by cardiac arrest, shock, and vasopressor use) who underwent MT/CDT from 2017 to 2020. We evaluated 1-year mortality using an inverse probability of treatment weighting approach, controlling for 62 baseline covariates. We also evaluated readmissions and in-hospital outcomes, including intracranial hemorr"],"journal":["JACC. Advances"],"pagination":["101706"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018976"],"repository":["biostudies-literature"],"pubmed_title":["Mechanical Thrombectomy vs Catheter-Directed Thrombolysis for High-Risk Pulmonary Embolism: A Target Trial Emulation."],"pmcid":["PMC12018976"],"pubmed_authors":["Kuno T","Tsugawa Y","Bangalore S","Ueyama HA","Watanabe A","Miyamoto Y","Gotanda H"],"additional_accession":[]},"is_claimable":false,"name":"Mechanical Thrombectomy vs Catheter-Directed Thrombolysis for High-Risk Pulmonary Embolism: A Target Trial Emulation.","description":"<h4>Background</h4>Evidence is limited regarding the comparative effectiveness and safety of mechanical thrombectomy (MT) vs catheter-directed thrombolysis (CDT) for high-risk pulmonary embolism (PE).<h4>Objectives</h4>This observational study aimed to compare the outcomes of older adults with high-risk PE treated with MT vs CDT using a target trial emulation framework.<h4>Methods</h4>We included Medicare fee-for-service beneficiaries aged 65 to 99 years admitted with high-risk PE (defined by cardiac arrest, shock, and vasopressor use) who underwent MT/CDT from 2017 to 2020. We evaluated 1-year mortality using an inverse probability of treatment weighting approach, controlling for 62 baseline covariates. We also evaluated readmissions and in-hospital outcomes, including intracranial hemorr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-06T03:04:12.61Z","creation":"2025-07-06T03:04:12.61Z"},"accession":"S-EPMC12018976","cross_references":{"pubmed":["40286366"],"doi":["10.1016/j.jacadv.2025.101706"]}}