{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aroeti L"],"funding":["European Research Council","Israel Academy of Sciences and Humanities"],"pagination":["3834"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12019536"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The RNA-binding protein CsrA regulates the expression of hundreds of genes in several bacterial species, thus controlling virulence and other processes. However, the outcome of the CsrA-mRNA interactions is modulated by competing small RNAs and other factors through mechanisms that are only partially understood. Here, we show that CsrA accumulates in a dynamic membraneless compartment in cells of E. coli and other pathogenic species. In addition to CsrA, the compartment contains components of the RNA-degrading complex (degradosome), regulatory small RNAs, and selected mRNAs. Formation of the compartment is associated with a switch between promoting and repressing virulence gene expression by CsrA. We suggest that similar CsrA switches may be widespread in diverse bacteria."],"journal":["Nature communications"],"pubmed_title":["Formation of a membraneless compartment regulates bacterial virulence."],"pmcid":["PMC12019536"],"funding_grant_id":["810186","833598","743/18"],"pubmed_authors":["Argaman L","Ravins M","Margalit H","Yakovian O","Altuvia Y","Faigenbaum-Romm R","Katsowich N","Ben-Yehuda S","Aroeti L","Rosenshine I","Bejerano-Sagie M","Elbaz N"],"additional_accession":[]},"is_claimable":false,"name":"Formation of a membraneless compartment regulates bacterial virulence.","description":"The RNA-binding protein CsrA regulates the expression of hundreds of genes in several bacterial species, thus controlling virulence and other processes. However, the outcome of the CsrA-mRNA interactions is modulated by competing small RNAs and other factors through mechanisms that are only partially understood. Here, we show that CsrA accumulates in a dynamic membraneless compartment in cells of E. coli and other pathogenic species. In addition to CsrA, the compartment contains components of the RNA-degrading complex (degradosome), regulatory small RNAs, and selected mRNAs. Formation of the compartment is associated with a switch between promoting and repressing virulence gene expression by CsrA. We suggest that similar CsrA switches may be widespread in diverse bacteria.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-02T10:14:50.258Z","creation":"2025-07-11T03:05:55.053Z"},"accession":"S-EPMC12019536","cross_references":{"pubmed":["40268935"],"doi":["10.1038/s41467-025-58829-9"]}}