biostudies-literatureUnknown97(15)Pieczonka SAMars Petcare UKGiven the long hardware lifespan, fixed installation, and comparatively high investment required to procure them, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) instruments tend to have a long operational life. The field is constantly evolving with rapidly advancing instrumental developments, and FT-ICR research groups work with a range of instrument designs from different generations. Consequently, compositional spectra comparability between instruments is a critical concern in FT-ICR-MS, particularly due to the variability introduced by commonly used direct infusion methods. This study demonstrates interlaboratory comparability of FT-ICR-MS molecular profiles using a 12 T solariX with an Infinity Cell and a 7 T scimaX with a ParaCell, with closely matched sample Analytical chemistry8491-8498https://www.ebi.ac.uk/biostudies/studies/S-EPMC12019771biostudies-literatureHarmonization of FT-ICR-MS Instruments for Interoperable Multi-Laboratory Comprehensive Compositional Profiling.PMC12019771Marshall JWThomas MJSchmitt-Kopplin PPieczonka SAfalseHarmonization of FT-ICR-MS Instruments for Interoperable Multi-Laboratory Comprehensive Compositional Profiling.Given the long hardware lifespan, fixed installation, and comparatively high investment required to procure them, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) instruments tend to have a long operational life. The field is constantly evolving with rapidly advancing instrumental developments, and FT-ICR research groups work with a range of instrument designs from different generations. Consequently, compositional spectra comparability between instruments is a critical concern in FT-ICR-MS, particularly due to the variability introduced by commonly used direct infusion methods. This study demonstrates interlaboratory comparability of FT-ICR-MS molecular profiles using a 12 T solariX with an Infinity Cell and a 7 T scimaX with a ParaCell, with closely matched sample 2025-01-01T00:00:00Z2025 Apr2025-06-26T03:05:41.547Z2025-06-26T03:05:41.547ZS-EPMC120197714020896310.1021/acs.analchem.5c00488