{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Antunes A"],"pubmed_abstract":["The venom of <i>Cyriopagopus schmidti</i> spider has been extensively investigated, thereby allowing the identification of numerous new natural peptides. Many of these peptides are active on ion channels and several of them occur from post-translational processing. In order to further identify new entities, we screened this venom against five different human voltage-gated sodium (hNa<sub>v</sub>) channels. We illustrate the unusual richness of this venom in targeting this wide variety of hNa<sub>v</sub> channels. We confirm the identity of previously discovered peptides active on these ion channels type (huwentoxin (HwTx)-I, HwTx-II and HwTx-IV), indicating the efficacy of the screening process by automated patch-clamp. We also identified a novel analogue of HwTx-IV that differs by the abs"],"journal":["Frontiers in pharmacology"],"pagination":["1566312"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12019880"],"repository":["biostudies-literature"],"pubmed_title":["The venom of &lt;i&gt;Cyriopagopus schmidti&lt;/i&gt; spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential."],"pmcid":["PMC12019880"],"pubmed_authors":["De Waard M","Benoit E","Servent D","Lopez L","Thomas B","Antunes A","Ribeiro Oliveira-Mendes B","Jaquillard L","Khakh K","Montnach J","Cohen CJ","Beroud R"],"additional_accession":[]},"is_claimable":false,"name":"The venom of &lt;i&gt;Cyriopagopus schmidti&lt;/i&gt; spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential.","description":"The venom of <i>Cyriopagopus schmidti</i> spider has been extensively investigated, thereby allowing the identification of numerous new natural peptides. Many of these peptides are active on ion channels and several of them occur from post-translational processing. In order to further identify new entities, we screened this venom against five different human voltage-gated sodium (hNa<sub>v</sub>) channels. We illustrate the unusual richness of this venom in targeting this wide variety of hNa<sub>v</sub> channels. We confirm the identity of previously discovered peptides active on these ion channels type (huwentoxin (HwTx)-I, HwTx-II and HwTx-IV), indicating the efficacy of the screening process by automated patch-clamp. We also identified a novel analogue of HwTx-IV that differs by the abs","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-06-26T03:05:27.25Z","creation":"2025-06-26T03:05:27.25Z"},"accession":"S-EPMC12019880","cross_references":{"pubmed":["40276610"],"doi":["10.3389/fphar.2025.1566312"]}}