{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Y"],"funding":["Key Technologies Research and Development Program","Science and Technology Development Fund","National Natural Science Foundation of China","China Postdoctoral Science Foundation","Suzhou Applied Basic Research (Healthcare) Science and Technology Innovation Program","National Key Research and Development Program of China"],"pagination":["e2416330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12021062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(16)"],"pubmed_abstract":["Current diagnostics for sepsis-associated acute kidney injury (SA-AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami-based nanoplatform is developed for the early diagnosis and treatment of SA-AKI. Modified with a fluorophore (Cy5) and quencher (BHQ3), the DNA origami remains nonfluorescent under normal conditions. During SA-AKI, elevated microRNA-21 triggers a strand displacement reaction that restores the fluorescence signal, enabling real-time detection. Additionally, the photoacoustic changes of BHQ3, driven by different excretion rates of the nanostructure and released DNA strands, enable dual-mode imaging, enhancing diagnostic accuracy. Therapeutically, DNA origami scavenges reactive oxygen species and, when conjugated wit"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["A Dual-Response DNA Origami Platform for Imaging and Treatment of Sepsis-Associated Acute Kidney Injury."],"pmcid":["PMC12021062"],"funding_grant_id":["2024M762281","SYW2024068","2023YFB3208200","0002/2022/AKP","0115/2023/RIA2","21825402","22074101","22393932"],"pubmed_authors":["Dong F","Ling Y","He Y","Chen Z","Lu X","Wang H","Zhao Y","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"A Dual-Response DNA Origami Platform for Imaging and Treatment of Sepsis-Associated Acute Kidney Injury.","description":"Current diagnostics for sepsis-associated acute kidney injury (SA-AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami-based nanoplatform is developed for the early diagnosis and treatment of SA-AKI. Modified with a fluorophore (Cy5) and quencher (BHQ3), the DNA origami remains nonfluorescent under normal conditions. During SA-AKI, elevated microRNA-21 triggers a strand displacement reaction that restores the fluorescence signal, enabling real-time detection. Additionally, the photoacoustic changes of BHQ3, driven by different excretion rates of the nanostructure and released DNA strands, enable dual-mode imaging, enhancing diagnostic accuracy. Therapeutically, DNA origami scavenges reactive oxygen species and, when conjugated wit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-29T17:11:57.536Z","creation":"2025-06-26T03:05:27.268Z"},"accession":"S-EPMC12021062","cross_references":{"pubmed":["40019357"],"doi":["10.1002/advs.202416330"]}}