{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pich O"],"funding":["Cancer Research UK","Agence Nationale de la Recherche","The Myelodysplastic Syndromes Foundation","National Institutes of Health","HORIZON EUROPE European Innovation Council","Royal Society","The Royal Society","European Molecular Biology Organization","Swiss National Science Foundation","European Research Council","Kay Kendall Leukaemia Fund","Horizon 2020 Framework Programme","Medical Research Council","EPA","European Hematology Association","NCI NIH HHS","Edward P Evans MDS Foundation","Leukaemia UK","Damon Runyon Cancer Research Foundation","Wellcome Trust","H2020 Marie Skłodowska-Curie Actions"],"pagination":["1594-1608"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12021423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["392(16)"],"pubmed_abstract":["<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH). The frequency of TI-CH and its effect on tumor evolution are unclear.<h4>Methods</h4>We characterized CHIP and TI-CH in 421 patients with early-stage non-small-cell lung cancer (NSCLC) from the TRACERx study and in 49,351 patients from the MSK-IMPACT pan-cancer cohort. We studied the association of TI-CH with survival and disease recurrence and evaluated the functional effect of <i>TET2</i>-mutant CHIP on the biologic features of lung tumors.<h4>Results</h4>Among patients with NSC"],"journal":["The New England journal of medicine"],"pubmed_title":["Tumor-Infiltrating Clonal Hematopoiesis."],"pmcid":["PMC12021423"],"funding_grant_id":["835297","CC2041, CC2027, CC2085, FC001070","P30 CA008748","CC2041","CC2085","EBSTF-2022/100044","838540","RF\\ERE\\210216","212304/Z/18/Z","RSRP\\R\\210001","TMAG-3_209224","101024529","KKL1397","RG112","ALTF 831-202","CA254838-01","WT209199/Z/17/Z","ANR-23-IAIHU-0002","834692","CC2097","890933","EP/Z534298/1","R35 CA263816","MR/N013867/1","101068227","CA263816","RCCCDF- Nov21\\100005","P50 CA254838","2021/JGF/002","EP-D-18-001","CC2027"],"pubmed_authors":["Bailey C","Swanton C","O'Sullivan J","Joyce JA","Wack A","Harris SK","Iliakis CS","Downward J","Lo Celso C","Quezada SA","Clark SA","Mead AJ","Huerga Encabo H","Malanchi I","Zagorulya M","Pich O","Zaidi R","Bonnet D","Scott R","Enfield KSS","Thol K","Pearce DR","Rane JK","Berger MF","Stonestrom AJ","Papazoglou D","Alvarez-Prado AF","Hackshaw A","Brierley CK","Magness A","Grey W","Papaemmanuil E","Rowan A","Dijkstra KK","Pospori C","Gronroos E","Green M","Slama R","Bola SK","Hynds RE","Jamal-Hanjani M","Anastasiou P","Barbe V","Hoxha E","Zaccaria S","Bernard E","Peggs KS","Rudin CM"],"additional_accession":[]},"is_claimable":false,"name":"Tumor-Infiltrating Clonal Hematopoiesis.","description":"<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH). The frequency of TI-CH and its effect on tumor evolution are unclear.<h4>Methods</h4>We characterized CHIP and TI-CH in 421 patients with early-stage non-small-cell lung cancer (NSCLC) from the TRACERx study and in 49,351 patients from the MSK-IMPACT pan-cancer cohort. We studied the association of TI-CH with survival and disease recurrence and evaluated the functional effect of <i>TET2</i>-mutant CHIP on the biologic features of lung tumors.<h4>Results</h4>Among patients with NSC","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-04-08T19:50:04.428Z","creation":"2025-07-01T03:05:06.835Z"},"accession":"S-EPMC12021423","cross_references":{"pubmed":["40267425"],"doi":["10.1056/NEJMoa2413361"]}}