{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ramos-Cabrer P"],"funding":["Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)","Eusko Jaurlaritza (Basque Government)","Ikerbasque, Basque Foundation for Science","Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)","Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación)"],"pagination":["697-703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12021653"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(4)"],"pubmed_abstract":["Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that the signal for myelin water fraction-a surrogate of myelin content-is substantially reduced upon marathon running in specific brain regions involved in motor coordination and sensory and emotional integration, but recovers within two months. These findings suggest that brain myelin content is temporarily and reversibly diminished by severe exercise, a finding consistent with recent evidence from rodent studies that suggest that myelin lipids may act as glial energy reserves in extreme metabolic conditions."],"journal":["Nature metabolism"],"pubmed_title":["Reversible reduction in brain myelin content upon marathon running."],"pmcid":["PMC12021653"],"funding_grant_id":["PRC","KK-2021/0009","CB06/05/0076","IT1551-22","PID2022-143020OB-I00","PID2020-118546RB-I00"],"pubmed_authors":["Cabrera-Zubizarreta A","Matute-Gonzalez M","Ramos-Cabrer P","Rodriguez-Antiguedad A","Matute C","Padro D"],"additional_accession":[]},"is_claimable":false,"name":"Reversible reduction in brain myelin content upon marathon running.","description":"Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that the signal for myelin water fraction-a surrogate of myelin content-is substantially reduced upon marathon running in specific brain regions involved in motor coordination and sensory and emotional integration, but recovers within two months. These findings suggest that brain myelin content is temporarily and reversibly diminished by severe exercise, a finding consistent with recent evidence from rodent studies that suggest that myelin lipids may act as glial energy reserves in extreme metabolic conditions.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:56.659Z","creation":"2025-07-10T03:08:56.659Z"},"accession":"S-EPMC12021653","cross_references":{"pubmed":["40128612"],"doi":["10.1038/s42255-025-01244-7"]}}