{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Streeter HB"],"pubmed_abstract":["<h4>Background</h4>Peptides were designed to induce immune tolerance to the major antigen associated with house dust mite (HDM) allergy, Der p 1. HDM is commonly associated with allergic responses in allergic rhinitis and asthma, with Der p 1 specific T-cells implicated in ongoing disease. Tolerogenic peptide immunotherapy can induce tolerance in pathogenic T-cells, bypass mast cell activation and hence reduce the risk of anaphylaxis. A pan-DR binding epitope of Der p 1, covering the broad population, was tested for efficacy in HLA-DR transgenic mice.<h4>Methods</h4>Potential pan-HLA-DR binding tolerogenic T-cell epitopes from Der p 1 were predicted <i>in silico</i> and manufactured (synthetic peptides A-E). Participants included HDM sensitised (allergic rhinitis/asthma, n=25), non-HDM sen"],"journal":["Frontiers in immunology"],"pagination":["1569283"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12021919"],"repository":["biostudies-literature"],"pubmed_title":["A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice."],"pmcid":["PMC12021919"],"pubmed_authors":["Streeter HB","Lucas LG","Krishna MT","Wraith DC","West RM"],"additional_accession":[]},"is_claimable":false,"name":"A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice.","description":"<h4>Background</h4>Peptides were designed to induce immune tolerance to the major antigen associated with house dust mite (HDM) allergy, Der p 1. HDM is commonly associated with allergic responses in allergic rhinitis and asthma, with Der p 1 specific T-cells implicated in ongoing disease. Tolerogenic peptide immunotherapy can induce tolerance in pathogenic T-cells, bypass mast cell activation and hence reduce the risk of anaphylaxis. A pan-DR binding epitope of Der p 1, covering the broad population, was tested for efficacy in HLA-DR transgenic mice.<h4>Methods</h4>Potential pan-HLA-DR binding tolerogenic T-cell epitopes from Der p 1 were predicted <i>in silico</i> and manufactured (synthetic peptides A-E). Participants included HDM sensitised (allergic rhinitis/asthma, n=25), non-HDM sen","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-09T03:04:47.88Z","creation":"2025-07-09T03:04:47.88Z"},"accession":"S-EPMC12021919","cross_references":{"pubmed":["40292297"],"doi":["10.3389/fimmu.2025.1569283"]}}