biostudies-literatureUnknown16Streeter HB<h4>Background</h4>Peptides were designed to induce immune tolerance to the major antigen associated with house dust mite (HDM) allergy, Der p 1. HDM is commonly associated with allergic responses in allergic rhinitis and asthma, with Der p 1 specific T-cells implicated in ongoing disease. Tolerogenic peptide immunotherapy can induce tolerance in pathogenic T-cells, bypass mast cell activation and hence reduce the risk of anaphylaxis. A pan-DR binding epitope of Der p 1, covering the broad population, was tested for efficacy in HLA-DR transgenic mice.<h4>Methods</h4>Potential pan-HLA-DR binding tolerogenic T-cell epitopes from Der p 1 were predicted <i>in silico</i> and manufactured (synthetic peptides A-E). Participants included HDM sensitised (allergic rhinitis/asthma, n=25), non-HDM senFrontiers in immunology1569283https://www.ebi.ac.uk/biostudies/studies/S-EPMC12021919biostudies-literatureA dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice.PMC12021919Streeter HBLucas LGKrishna MTWraith DCWest RMfalseA dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice.<h4>Background</h4>Peptides were designed to induce immune tolerance to the major antigen associated with house dust mite (HDM) allergy, Der p 1. HDM is commonly associated with allergic responses in allergic rhinitis and asthma, with Der p 1 specific T-cells implicated in ongoing disease. Tolerogenic peptide immunotherapy can induce tolerance in pathogenic T-cells, bypass mast cell activation and hence reduce the risk of anaphylaxis. A pan-DR binding epitope of Der p 1, covering the broad population, was tested for efficacy in HLA-DR transgenic mice.<h4>Methods</h4>Potential pan-HLA-DR binding tolerogenic T-cell epitopes from Der p 1 were predicted <i>in silico</i> and manufactured (synthetic peptides A-E). Participants included HDM sensitised (allergic rhinitis/asthma, n=25), non-HDM sen2025-01-01T00:00:00Z20252025-07-09T03:04:47.88Z2025-07-09T03:04:47.88ZS-EPMC120219194029229710.3389/fimmu.2025.1569283