{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["D'Aprile S"],"pubmed_abstract":["Glioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12-15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity, recurrencies, and resistance. Metabolic reshaping is emerging as a critical mechanism supporting cell proliferation and sustaining chemoresistance. In this study, we explored metabolic changes induced by chemotherapy in temozolomide (TMZ)-sensitive and TMZ-resistant GBM cell lines. We found that purine levels were altered in sensitive versus resistant GBM cells, highlighting a critical role of guanosine and inosine metabolism. By using a mesenchymal-like GBM zebrafish model, we uncovered dysregulated pathways involved in purine metabolism, with a dow"],"journal":["Cell death & disease"],"pagination":["336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12022057"],"repository":["biostudies-literature"],"pubmed_title":["Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment."],"pmcid":["PMC12022057"],"pubmed_authors":["Bucolo C","D'Aprile S","Denaro S","Li Volti G","Mione MC","Torrisi F","Parenti R","Giallongo C","Amorini AM","Vicario N","Jorgacevski J","Longhitano L","Tibullo D","Drago F","Bontempi V","Giallongo S","Potokar M","Zorec R"],"additional_accession":[]},"is_claimable":false,"name":"Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment.","description":"Glioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12-15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity, recurrencies, and resistance. Metabolic reshaping is emerging as a critical mechanism supporting cell proliferation and sustaining chemoresistance. In this study, we explored metabolic changes induced by chemotherapy in temozolomide (TMZ)-sensitive and TMZ-resistant GBM cell lines. We found that purine levels were altered in sensitive versus resistant GBM cells, highlighting a critical role of guanosine and inosine metabolism. By using a mesenchymal-like GBM zebrafish model, we uncovered dysregulated pathways involved in purine metabolism, with a dow","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-03T01:14:26.248Z","creation":"2025-07-12T03:03:53.727Z"},"accession":"S-EPMC12022057","cross_references":{"pubmed":["40274776"],"doi":["10.1038/s41419-025-07667-0"]}}