{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hanna DA"],"funding":["NIH National Institute of General Medical Sciences","National Institutes of Health","NIGMS NIH HHS"],"pagination":["108433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12022479"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["301(5)"],"pubmed_abstract":["Mitochondrial form and function are intimately interconnected, responding to cellular stresses and changes in energy demand. Hydrogen sulfide, a product of amino acid metabolism, has dual roles as an electron transport chain substrate and complex IV (CIV) inhibitor, leading to a reductive shift, which has pleiotropic metabolic consequences. Luminal sulfide concentration in the colon is high due to microbial activity, and in this study, we demonstrate that chronic sulfide exposure of colonocyte-derived cells leads to lower Mic60 and Mic19 expression that is correlated with a profound loss of cristae and lower mitochondrial networking. Sulfide-induced depolarization of the inner mitochondrial membrane activates Oma1-dependent cleavage of Opa1 and is associated with a profound loss of CI and "],"journal":["The Journal of biological chemistry"],"pubmed_title":["H<sub>2</sub>S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes."],"pmcid":["PMC12022479"],"funding_grant_id":["GM130183","F32GM140694","R35 GM131701","F32 GM140694","R01 GM143250","GM131701\\u201301","R35 GM130183"],"pubmed_authors":["Banerjee R","Hanna DA","Cunniff B","Khalimonchuk O","Shah YM","Chen B"],"additional_accession":[]},"is_claimable":false,"name":"H<sub>2</sub>S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes.","description":"Mitochondrial form and function are intimately interconnected, responding to cellular stresses and changes in energy demand. Hydrogen sulfide, a product of amino acid metabolism, has dual roles as an electron transport chain substrate and complex IV (CIV) inhibitor, leading to a reductive shift, which has pleiotropic metabolic consequences. Luminal sulfide concentration in the colon is high due to microbial activity, and in this study, we demonstrate that chronic sulfide exposure of colonocyte-derived cells leads to lower Mic60 and Mic19 expression that is correlated with a profound loss of cristae and lower mitochondrial networking. Sulfide-induced depolarization of the inner mitochondrial membrane activates Oma1-dependent cleavage of Opa1 and is associated with a profound loss of CI and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T19:06:18.186Z","creation":"2026-04-19T03:14:05.326Z"},"accession":"S-EPMC12022479","cross_references":{"pubmed":["40120684"],"doi":["10.1016/j.jbc.2025.108433"]}}