{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jung LB"],"funding":["NIA NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["e2428687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12025916"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(8)"],"pubmed_abstract":["Importance
Exposure to repetitive head impacts (RHI) is associated with increased risk for neurodegeneration. Accumulation of toxic proteins due to impaired brain clearance is suspected to play a role.Objective
To investigate whether perivascular space (PVS) volume is associated with lifetime exposure to RHI in individuals at risk for RHI-associated neurodegeneration.Design, setting, and participants
This cross-sectional study was part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project, a 7-year multicenter study consisting of 4 US study sites. Data were collected from September 2016 to February 2020 and analyses were performed between May 2021 and October 2023."],"journal":["JAMA network open"],"pubmed_title":["Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players."],"pmcid":["PMC12025916"],"funding_grant_id":["RF1 MH123223","R01 NS129573","U01 NS093334","R01 NS100952","K00 NS113419","P30 AG072980"],"pubmed_authors":["Mez J","Golceker M","Fagle T","Hasanaj L","Al-Kharafi A","Durant J","Sestak M","Duffy A","Piantino J","Su Y","Martin S","Kirov I","Sandoval P","Runge W","Simkin I","Sabbagh M","Stern RA","Coleman MJ","Banks S","Harmon N","Bouix S","Marmar C","Serrano A","Platt T","McLaughlin K","Sepehrband F","Ritter A","Rica F","Silva A","Daneshvar DH","Otis J","Serrano L","Koerte IK","Protas H","Shenton ME","Diamond C","Riley E","Arciniega H","de la Cruz R","Miller J","Turner RW","Peskind ER","Osgood T","George A","Dodick DW","Weller J","McClean M","Howard M","Johnson KA","Liao H","Bernick C","Hartlage K","Ramachandran J","Annis D","Gallagher K","Nance C","Tuz-Zahra F","Ojo E","Colasurdo E","Nanna M","Tripodis Y","Barr W","Lui Y","Breedlove K","Pankatz L","Bonke EM","Haller O","Wiegand TLT","Cummings JL","Andino A","Wisniewski T","Helm R","Kim CL","Marcus DS","Gullotti N","Geda Y","Lin AP","Iliff JJ","Balcer L","Greenwald R","Au R","Kowall N","Goldberg J","Fitzsimmons J","Reiman EM","Dixon DB","Marek KL","Chen K","Rathi Y","Pulukuri S","DIAGNOSE CTE Research Project","Lu J","Farrer L","Falk B","Jung LB","Conneely S","Chaisson C","Babcock D","Finney C","Pine B","Long R","Kaylegian K","Schultz V","Alosco ML","Montague M","Gurney J","Hung T","Mariani M","Coello E","Pasternak O","Adler CH","Rizzoni E","Palmisano JN","Mayville B","Mercier G","Martin B","Boker C","Cantu RC","Vessey B","Wethe JV"],"additional_accession":[]},"is_claimable":false,"name":"Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players.","description":"Importance
Exposure to repetitive head impacts (RHI) is associated with increased risk for neurodegeneration. Accumulation of toxic proteins due to impaired brain clearance is suspected to play a role.Objective
To investigate whether perivascular space (PVS) volume is associated with lifetime exposure to RHI in individuals at risk for RHI-associated neurodegeneration.Design, setting, and participants
This cross-sectional study was part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project, a 7-year multicenter study consisting of 4 US study sites. Data were collected from September 2016 to February 2020 and analyses were performed between May 2021 and October 2023.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-17T15:33:22.153Z","creation":"2025-08-16T03:07:08.157Z"},"accession":"S-EPMC12025916","cross_references":{"pubmed":["39186275"],"doi":["10.1001/jamanetworkopen.2024.28687"]}}