biostudies-literatureJung LBNIA NIH HHSNIMH NIH HHSNINDS NIH HHSe2428687https://www.ebi.ac.uk/biostudies/studies/S-EPMC12025916biostudies-literatureUnknown7(8)<h4>Importance</h4>Exposure to repetitive head impacts (RHI) is associated with increased risk for neurodegeneration. Accumulation of toxic proteins due to impaired brain clearance is suspected to play a role.<h4>Objective</h4>To investigate whether perivascular space (PVS) volume is associated with lifetime exposure to RHI in individuals at risk for RHI-associated neurodegeneration.<h4>Design, setting, and participants</h4>This cross-sectional study was part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project, a 7-year multicenter study consisting of 4 US study sites. Data were collected from September 2016 to February 2020 and analyses were performed between May 2021 and October 2023.JAMA network openRepetitive Head Impacts and Perivascular Space Volume in Former American Football Players.PMC12025916RF1 MH123223R01 NS129573U01 NS093334R01 NS100952K00 NS113419P30 AG072980Mez JGolceker MFagle THasanaj LAl-Kharafi ADurant JSestak MDuffy APiantino JSu YMartin SKirov ISandoval PRunge WSimkin ISabbagh MStern RAColeman MJBanks SHarmon NBouix SMarmar CSerrano APlatt TMcLaughlin KSepehrband FRitter ARica FSilva ADaneshvar DHOtis JSerrano LKoerte IKProtas HShenton MEDiamond CRiley EArciniega Hde la Cruz RMiller JTurner RWPeskind EROsgood TGeorge ADodick DWWeller JMcClean MHoward MJohnson KALiao HBernick CHartlage KRamachandran JAnnis DGallagher KNance CTuz-Zahra FOjo EColasurdo ENanna MTripodis YBarr WLui YBreedlove KPankatz LBonke EMHaller OWiegand TLTCummings JLAndino AWisniewski THelm RKim CLMarcus DSGullotti NGeda YLin APIliff JJBalcer LGreenwald RAu RKowall NGoldberg JFitzsimmons JReiman EMDixon DBMarek KLChen KRathi YPulukuri SDIAGNOSE CTE Research ProjectLu JFarrer LFalk BJung LBConneely SChaisson CBabcock DFinney CPine BLong RKaylegian KSchultz VAlosco MLMontague MGurney JHung TMariani MCoello EPasternak OAdler CHRizzoni EPalmisano JNMayville BMercier GMartin BBoker CCantu RCVessey BWethe JVfalseRepetitive Head Impacts and Perivascular Space Volume in Former American Football Players.<h4>Importance</h4>Exposure to repetitive head impacts (RHI) is associated with increased risk for neurodegeneration. Accumulation of toxic proteins due to impaired brain clearance is suspected to play a role.<h4>Objective</h4>To investigate whether perivascular space (PVS) volume is associated with lifetime exposure to RHI in individuals at risk for RHI-associated neurodegeneration.<h4>Design, setting, and participants</h4>This cross-sectional study was part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project, a 7-year multicenter study consisting of 4 US study sites. Data were collected from September 2016 to February 2020 and analyses were performed between May 2021 and October 2023.2024-01-01T00:00:00Z2024 Aug2026-03-17T15:33:22.153Z2025-08-16T03:07:08.157ZS-EPMC120259163918627510.1001/jamanetworkopen.2024.28687