biostudies-literatureIoakeim-Skoufa ICarlos III Institute of Health2615https://www.ebi.ac.uk/biostudies/studies/S-EPMC12028097biostudies-literatureUnknown14(8)<b>Background:</b> Managing multimorbidity is a major challenge for healthcare systems. Cardiometabolic multimorbidity (CMM) is highly prevalent and linked to increased disease burden, functional decline, and mortality. While most studies focus on cross-sectional analyses, longitudinal approaches are essential for understanding disease progression and identifying patient groups who may benefit from targeted interventions. <b>Objectives:</b> This systematic review synthesises evidence from longitudinal studies on the incidence and progression of CMM, exploring transitions between multimorbidity clusters and their clinical implications. <b>Methods:</b> A systematic search was conducted in MEDLINE and EMBASE following PRISMA guidelines. Studies were included if they employed longitudinal desiJournal of clinical medicineCharting the Pathways of Cardiometabolic Multimorbidity: A Systematic Review of Clinical Trajectories.PMC12028097RD21/0016/0019Hernandez-Rodriguez MAAza-Pascual-Salcedo MAvedillo-Salas AGimeno-Miguel ALedesma-Calvo RIoakeim-Skoufa IMoreno-Juste ACebollada-Herrera CAtkins KLasala-Aza CGonzalez-Rubio FEsteban-Jimenez OVicente-Romero JRoque FfalseCharting the Pathways of Cardiometabolic Multimorbidity: A Systematic Review of Clinical Trajectories.<b>Background:</b> Managing multimorbidity is a major challenge for healthcare systems. Cardiometabolic multimorbidity (CMM) is highly prevalent and linked to increased disease burden, functional decline, and mortality. While most studies focus on cross-sectional analyses, longitudinal approaches are essential for understanding disease progression and identifying patient groups who may benefit from targeted interventions. <b>Objectives:</b> This systematic review synthesises evidence from longitudinal studies on the incidence and progression of CMM, exploring transitions between multimorbidity clusters and their clinical implications. <b>Methods:</b> A systematic search was conducted in MEDLINE and EMBASE following PRISMA guidelines. Studies were included if they employed longitudinal desi2025-01-01T00:00:00Z2025 Apr2025-07-03T03:04:45.535Z2025-07-03T03:04:45.535ZS-EPMC120280974028344510.3390/jcm14082615