{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rani A"],"funding":["Deanship of Scientific Research at King Khalid University"],"pagination":["478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12030045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["<b>Background:</b> Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach for an effective treatment of psoriasis. <b>Methods</b>: Initially, HPD-NLC was optimized with independent variables (drug content, amount of liquid lipid, total lipid, and surfactant concentration) using Box-Behnken Design to assess dependent variables (particle size, size distribution, and entrapment efficiency). HPD-NLC was developed using the high-shear homogenization technique. The characteristics of nanoformulation such as particle size, morphology [transmission electron microscopy (TEM) and"],"journal":["Pharmaceutics"],"pubmed_title":["Nanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment of Psoriasis."],"pmcid":["PMC12030045"],"funding_grant_id":["RGP2/402/45"],"pubmed_authors":["Vasudevan R","Aldahish A","Sharma R","Dora CP","Chandrasekaran B","Singh TG","Rani A","Kaur R","Balaji P"],"additional_accession":[]},"is_claimable":false,"name":"Nanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment of Psoriasis.","description":"<b>Background:</b> Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach for an effective treatment of psoriasis. <b>Methods</b>: Initially, HPD-NLC was optimized with independent variables (drug content, amount of liquid lipid, total lipid, and surfactant concentration) using Box-Behnken Design to assess dependent variables (particle size, size distribution, and entrapment efficiency). HPD-NLC was developed using the high-shear homogenization technique. The characteristics of nanoformulation such as particle size, morphology [transmission electron microscopy (TEM) and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:04:29.332Z","creation":"2025-07-03T03:04:29.332Z"},"accession":"S-EPMC12030045","cross_references":{"pubmed":["40284473"],"doi":["10.3390/pharmaceutics17040478"]}}