biostudies-literatureRani ADeanship of Scientific Research at King Khalid University478https://www.ebi.ac.uk/biostudies/studies/S-EPMC12030045biostudies-literatureUnknown17(4)<b>Background:</b> Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach for an effective treatment of psoriasis. <b>Methods</b>: Initially, HPD-NLC was optimized with independent variables (drug content, amount of liquid lipid, total lipid, and surfactant concentration) using Box-Behnken Design to assess dependent variables (particle size, size distribution, and entrapment efficiency). HPD-NLC was developed using the high-shear homogenization technique. The characteristics of nanoformulation such as particle size, morphology [transmission electron microscopy (TEM) andPharmaceuticsNanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment of Psoriasis.PMC12030045RGP2/402/45Vasudevan RAldahish ASharma RDora CPChandrasekaran BSingh TGRani AKaur RBalaji PfalseNanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment of Psoriasis.<b>Background:</b> Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach for an effective treatment of psoriasis. <b>Methods</b>: Initially, HPD-NLC was optimized with independent variables (drug content, amount of liquid lipid, total lipid, and surfactant concentration) using Box-Behnken Design to assess dependent variables (particle size, size distribution, and entrapment efficiency). HPD-NLC was developed using the high-shear homogenization technique. The characteristics of nanoformulation such as particle size, morphology [transmission electron microscopy (TEM) and2025-01-01T00:00:00Z2025 Apr2025-07-03T03:04:29.332Z2025-07-03T03:04:29.332ZS-EPMC120300454028447310.3390/pharmaceutics17040478