{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang S"],"funding":["Shanghai Municipal Science and Technology Major Project","Science and Technology Commission of Shanghai Municipality"],"pagination":["302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12030110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(4)"],"pubmed_abstract":["(1) Background: The treatment of <i>Mycobacterium abscessus</i> (<i>M. abscessus</i>) infections resistant to clarithromycin (CLR) is highly challenging. Traditional non-tuberculous mycobacteria (NTM) chemotherapy may disturb the immune homeostasis of the host by increasing oxidative stress; therefore, host-directed immunotherapy is an alternative option for infections caused by <i>M. abscessus</i>. (2) Method: A clinical isolate of CLR-resistant <i>M. abscessus</i> was screened, and then the therapeutic effects of N-acetylcysteine (NAC) against CLR-resistant <i>M. abscessus</i> infection were evaluated in Tohoku Hospital Pediatrics-1 (THP-1) cells and murine models. RNA sequencing and Western blot were used to profile the protective immune responses induced by NAC. The contribution of can"],"journal":["Pathogens (Basel, Switzerland)"],"pubmed_title":["N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant &lt;i&gt;Mycobacterium abscessus&lt;/i&gt;."],"pmcid":["PMC12030110"],"funding_grant_id":["ZD2021CY001","21Y11901700","20Z11901002"],"pubmed_authors":["Liu J","Ma R","Fan X","Dong Y","Hu Z","Ren Y","Huang H","Li F","Xu J","Xie S","Chen Z","Long Y","Zhang Y","Huang X","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant &lt;i&gt;Mycobacterium abscessus&lt;/i&gt;.","description":"(1) Background: The treatment of <i>Mycobacterium abscessus</i> (<i>M. abscessus</i>) infections resistant to clarithromycin (CLR) is highly challenging. Traditional non-tuberculous mycobacteria (NTM) chemotherapy may disturb the immune homeostasis of the host by increasing oxidative stress; therefore, host-directed immunotherapy is an alternative option for infections caused by <i>M. abscessus</i>. (2) Method: A clinical isolate of CLR-resistant <i>M. abscessus</i> was screened, and then the therapeutic effects of N-acetylcysteine (NAC) against CLR-resistant <i>M. abscessus</i> infection were evaluated in Tohoku Hospital Pediatrics-1 (THP-1) cells and murine models. RNA sequencing and Western blot were used to profile the protective immune responses induced by NAC. The contribution of can","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T19:43:15.717Z","creation":"2025-07-12T03:04:11.167Z"},"accession":"S-EPMC12030110","cross_references":{"pubmed":["40333083"],"doi":["10.3390/pathogens14040302"]}}