{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie J"],"funding":["The Key Research and Development Project of Ningxia Hui Autonomous Region","Research and Demonstration of Grassland Ecological Restoration Technology Model along the Silk Road"],"pagination":["1180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12030360"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(8)"],"pubmed_abstract":["G-quadruplexes play a crucial role in transcription, translation, and DNA replication in plant genomes. Here, we comprehensively examined the prevalence and functions of G-quadruplexes in <i>Vitis vinifera</i>. A total of 467,813 G-quadruplexes were identified in grapevine genome, with enrichment in the promoter (0.54/kbp) and near transcription start sites (TSSs, 1.00/kbp), and showed conservative strand preference. The G-quadruplex density in centromeres exhibited heterogeneity. The differentially expressed genes (DEGs) under two-day drought stress manifested high G-quadruplex density in the promoter and TSS regions. The upregulated DEGs showed template strand-biased G-quadruplex enrichment, while downregulated DEGs displayed coding strand dominance linked to metal ion homeostasis and su"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["Decoding G-Quadruplexes Sequence in &lt;i&gt;Vitis vinifera&lt;/i&gt;: Regulatory Region Enrichment, Drought Stress Adaptation, and Sugar-Acid Metabolism Modulation."],"pmcid":["PMC12030360"],"funding_grant_id":["2024BBF01002","KY202002011"],"pubmed_authors":["Qiao G","Jia Q","Song K","Liu Y","Li Y","Xu M","Wang R","Xie J","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Decoding G-Quadruplexes Sequence in &lt;i&gt;Vitis vinifera&lt;/i&gt;: Regulatory Region Enrichment, Drought Stress Adaptation, and Sugar-Acid Metabolism Modulation.","description":"G-quadruplexes play a crucial role in transcription, translation, and DNA replication in plant genomes. Here, we comprehensively examined the prevalence and functions of G-quadruplexes in <i>Vitis vinifera</i>. A total of 467,813 G-quadruplexes were identified in grapevine genome, with enrichment in the promoter (0.54/kbp) and near transcription start sites (TSSs, 1.00/kbp), and showed conservative strand preference. The G-quadruplex density in centromeres exhibited heterogeneity. The differentially expressed genes (DEGs) under two-day drought stress manifested high G-quadruplex density in the promoter and TSS regions. The upregulated DEGs showed template strand-biased G-quadruplex enrichment, while downregulated DEGs displayed coding strand dominance linked to metal ion homeostasis and su","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-04-22T03:27:59.01Z","creation":"2025-07-07T03:08:20.687Z"},"accession":"S-EPMC12030360","cross_references":{"pubmed":["40284068"],"doi":["10.3390/plants14081180"]}}