{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Franca RKAO"],"funding":["Fundação Universidade de Brasília","Fundação de Apoio à Pesquisa do Distrito Federal","Coordenação de Aperfeicoamento de Pessoal de Nível Superior"],"pagination":["393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12031002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Background
The COVID-19 pandemic has spurred a global race for a preventive vaccine, with a few becoming available just one year after describing this novel coronavirus disease. Among these are inactivated virus vaccines like CoronaVac (Sinovac Biotech), which are used in several countries to reduce the pandemic's effects. However, its use was associated with low protection, particularly against novel virus variants that quickly appeared in the following months. Vaccines play a crucial role in activating the immune system to combat infections, with Memory B-cells being a key part of this mechanism, eliciting protective neutralizing antibodies. This work focused on studying B-cell memory repertoire after two consecutive doses of CoronaVac.Methodology
Memory B-cells were isol"],"journal":["Vaccines"],"pubmed_title":["Naive and Memory B Cell BCR Repertoires in Individuals Immunized with an Inactivated SARS-CoV-2 Vaccine."],"pmcid":["PMC12031002"],"funding_grant_id":["001","DPI-COPEI 7181","00193-00001263/2021-12"],"pubmed_authors":["Franca RKAO","Silva JM","Fontinele HGC","Barros PHA","Brigido MM","Maranhao AQ"],"additional_accession":[]},"is_claimable":false,"name":"Naive and Memory B Cell BCR Repertoires in Individuals Immunized with an Inactivated SARS-CoV-2 Vaccine.","description":"Background
The COVID-19 pandemic has spurred a global race for a preventive vaccine, with a few becoming available just one year after describing this novel coronavirus disease. Among these are inactivated virus vaccines like CoronaVac (Sinovac Biotech), which are used in several countries to reduce the pandemic's effects. However, its use was associated with low protection, particularly against novel virus variants that quickly appeared in the following months. Vaccines play a crucial role in activating the immune system to combat infections, with Memory B-cells being a key part of this mechanism, eliciting protective neutralizing antibodies. This work focused on studying B-cell memory repertoire after two consecutive doses of CoronaVac.Methodology
Memory B-cells were isol","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-03T03:27:06.201Z","creation":"2025-07-06T03:03:48.355Z"},"accession":"S-EPMC12031002","cross_references":{"pubmed":["40333337"],"doi":["10.3390/vaccines13040393"]}}