biostudies-literatureBarbaroux HBritish Heart FoundationNHLBI NIH HHSEPSRC Centre for Doctoral Training in Smart Medical Imaging101866https://www.ebi.ac.uk/biostudies/studies/S-EPMC12032873biostudies-literatureUnknown27(1)<h4>Background</h4>Myocardial strain is a valuable biomarker for diagnosing and predicting cardiac conditions, offering additional prognostic information to traditional metrics such as ejection fraction. While cardiovascular magnetic resonance (CMR) methods, particularly cine displacement encoding with stimulated echoes (DENSE), are the gold standard for strain estimation, evaluation of regional strain estimation requires precise ground truth. This study introduces DENSE-SIM, an open-source simulation pipeline for generating realistic cine DENSE images with high-resolution known ground-truth strain, enabling evaluation of accuracy and precision in strain analysis pipelines.<h4>Methods</h4>This pipeline is a modular tool designed for simulating cine DENSE images and evaluating strain estimaJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceDENSE-SIM: A modular pipeline for the evaluation of cine displacement encoding with stimulated echoes images with sub-voxel ground-truth strain.PMC12032873RG/19/1/34160R01 HL131823Loecher MBrackenier YNeji RNielles-Vallespin SBarbaroux HPennell DJScott ADYoung AAKunze KPEnnis DBfalseDENSE-SIM: A modular pipeline for the evaluation of cine displacement encoding with stimulated echoes images with sub-voxel ground-truth strain.<h4>Background</h4>Myocardial strain is a valuable biomarker for diagnosing and predicting cardiac conditions, offering additional prognostic information to traditional metrics such as ejection fraction. While cardiovascular magnetic resonance (CMR) methods, particularly cine displacement encoding with stimulated echoes (DENSE), are the gold standard for strain estimation, evaluation of regional strain estimation requires precise ground truth. This study introduces DENSE-SIM, an open-source simulation pipeline for generating realistic cine DENSE images with high-resolution known ground-truth strain, enabling evaluation of accuracy and precision in strain analysis pipelines.<h4>Methods</h4>This pipeline is a modular tool designed for simulating cine DENSE images and evaluating strain estima2025-01-01T00:00:00Z2025 Summer2026-06-03T12:04:44.682Z2025-07-06T03:04:01.605ZS-EPMC120328733998829810.1016/j.jocmr.2025.101866