{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45"],"submitter":["Seidel F"],"pubmed_abstract":["<h4>Background</h4>Obesity in mid-adulthood has been suggested to promote brain aging and is associated with progressive cognitive impairment later in life. However, the structural and functional alterations that underlie obesity-related cognitive dysfunction are still poorly understood, partly owing to the lack of translational models replicating age- and obesity-related brain pathology.<h4>Methods</h4>The effect of age and high-fat diet (HFD)-induced obesity was investigated in adult Ldlr-/-.Leiden mice, an established translational model for obesity and its comorbidities. During mid-adulthood, from three to eight months of age, brain structure and function (hippocampal volume, cortical thickness, white matter integrity, cerebral blood flow (CBF), resting-state functional connectivity) w"],"journal":["Brain, behavior, & immunity - health"],"pagination":["100991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12032874"],"repository":["biostudies-literature"],"pubmed_title":["Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice."],"pmcid":["PMC12032874"],"pubmed_authors":["Verweij V","Snabel J","Kiliaan AJ","de Ruiter C","van Duyvenvoorde W","Geenen B","Seidel F","Morrison MC","Attema J","Wiesmann M","Arnoldussen I","Franco A","Kleemann R"],"additional_accession":[]},"is_claimable":false,"name":"Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.","description":"<h4>Background</h4>Obesity in mid-adulthood has been suggested to promote brain aging and is associated with progressive cognitive impairment later in life. However, the structural and functional alterations that underlie obesity-related cognitive dysfunction are still poorly understood, partly owing to the lack of translational models replicating age- and obesity-related brain pathology.<h4>Methods</h4>The effect of age and high-fat diet (HFD)-induced obesity was investigated in adult Ldlr-/-.Leiden mice, an established translational model for obesity and its comorbidities. During mid-adulthood, from three to eight months of age, brain structure and function (hippocampal volume, cortical thickness, white matter integrity, cerebral blood flow (CBF), resting-state functional connectivity) w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T19:06:05.398Z","creation":"2025-07-03T03:04:06.621Z"},"accession":"S-EPMC12032874","cross_references":{"pubmed":["40291340"],"doi":["10.1016/j.bbih.2025.100991"]}}