biostudies-literatureUnknown45Seidel F<h4>Background</h4>Obesity in mid-adulthood has been suggested to promote brain aging and is associated with progressive cognitive impairment later in life. However, the structural and functional alterations that underlie obesity-related cognitive dysfunction are still poorly understood, partly owing to the lack of translational models replicating age- and obesity-related brain pathology.<h4>Methods</h4>The effect of age and high-fat diet (HFD)-induced obesity was investigated in adult Ldlr-/-.Leiden mice, an established translational model for obesity and its comorbidities. During mid-adulthood, from three to eight months of age, brain structure and function (hippocampal volume, cortical thickness, white matter integrity, cerebral blood flow (CBF), resting-state functional connectivity) wBrain, behavior, & immunity - health100991https://www.ebi.ac.uk/biostudies/studies/S-EPMC12032874biostudies-literatureObesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.PMC12032874Verweij VSnabel JKiliaan AJde Ruiter Cvan Duyvenvoorde WGeenen BSeidel FMorrison MCAttema JWiesmann MArnoldussen IFranco AKleemann RfalseObesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.<h4>Background</h4>Obesity in mid-adulthood has been suggested to promote brain aging and is associated with progressive cognitive impairment later in life. However, the structural and functional alterations that underlie obesity-related cognitive dysfunction are still poorly understood, partly owing to the lack of translational models replicating age- and obesity-related brain pathology.<h4>Methods</h4>The effect of age and high-fat diet (HFD)-induced obesity was investigated in adult Ldlr-/-.Leiden mice, an established translational model for obesity and its comorbidities. During mid-adulthood, from three to eight months of age, brain structure and function (hippocampal volume, cortical thickness, white matter integrity, cerebral blood flow (CBF), resting-state functional connectivity) w2025-01-01T00:00:00Z2025 May2026-06-02T19:06:05.398Z2025-07-03T03:04:06.621ZS-EPMC120328744029134010.1016/j.bbih.2025.100991