{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Playter C"],"funding":["NIH National Institute of General Medical Sciences","National Institutes of Health","NIGMS NIH HHS"],"pagination":["112346"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12032941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(5)"],"pubmed_abstract":["Metastatic cancer cells traverse constricted spaces that exert forces on their nucleus and the genomic contents within. Cancerous tumors are highly heterogeneous and not all cells within them can achieve such a feat. Here, we investigated what initial genome architecture characteristics favor the constricted migratory ability of cancer cells and which arise only after passage through multiple constrictions. We identified a cell surface protein (ITGB4) whose expression correlates with increased initial constricted migration ability in human melanoma A375 cells. Sorting out this subpopulation allowed us to identify cellular and nuclear features that pre-exist and favor migration, as well as alterations that only appear after cells have passed through constrictions. We identified specific gen"],"journal":["iScience"],"pubmed_title":["Deciphering pre-existing and induced 3D genome architecture changes involved in constricted melanoma migration."],"pmcid":["PMC12032941"],"funding_grant_id":["R35GM133557","R35 GM133557"],"pubmed_authors":["McCord RP","Saad A","Benson SJ","Golloshi R","Rodriguez Gonzalez A","Playter C","Garretson JH","Olajide TH"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering pre-existing and induced 3D genome architecture changes involved in constricted melanoma migration.","description":"Metastatic cancer cells traverse constricted spaces that exert forces on their nucleus and the genomic contents within. Cancerous tumors are highly heterogeneous and not all cells within them can achieve such a feat. Here, we investigated what initial genome architecture characteristics favor the constricted migratory ability of cancer cells and which arise only after passage through multiple constrictions. We identified a cell surface protein (ITGB4) whose expression correlates with increased initial constricted migration ability in human melanoma A375 cells. Sorting out this subpopulation allowed us to identify cellular and nuclear features that pre-exist and favor migration, as well as alterations that only appear after cells have passed through constrictions. We identified specific gen","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-05-29T17:11:59.989Z","creation":"2025-07-03T03:04:28.875Z"},"accession":"S-EPMC12032941","cross_references":{"pubmed":["40292313"],"doi":["10.1016/j.isci.2025.112346"]}}