{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Agarwal S"],"funding":["FDA HHS","NIAMS NIH HHS","NIH","United States Food and Drug Administration"],"pagination":["38-49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12034093"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(1)"],"pubmed_abstract":["Pregnancy and lactation-associated osteoporosis (PLO) is a rare presentation of early-onset osteoporosis characterized by low trauma and spontaneous fractures during late pregnancy/lactation. Herein, we report areal BMD (aBMD) by DXA and volumetric BMD (vBMD), microarchitecture, and strength at the distal radius and tibia by HR-pQCT in 59 women with PLO-in comparison to both healthy premenopausal controls (n = 28) and premenopausal women with idiopathic osteoporotic fractures not associated with pregnancy/lactation (non-PLO IOP; n = 50). Women with PLO (aged 34 ± 6 yr) had a more severe clinical presentation than non-PLO IOP: 80% had vertebral and 92% had multiple fractures (p<.001). They had lower DXA aBMD at all sites vs Controls (all p<.001) and non-PLO IOP (all p<.05). By HR-pQCT, PLO "],"journal":["Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"],"pubmed_title":["HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO)."],"pmcid":["PMC12034093"],"funding_grant_id":["K23 AR054127","R01 FD003902","R01 FD006007","FDA RO1 FD006007","R01 AR049896"],"pubmed_authors":["Stubby J","Agarwal S","Kamanda-Kosseh M","Kondapalli A","Guo XE","El-Najjar D","Kil N","Shane E","Cohen A","Bucovsky M","Colon I","Recker RR","Lappe JM"],"additional_accession":[]},"is_claimable":false,"name":"HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO).","description":"Pregnancy and lactation-associated osteoporosis (PLO) is a rare presentation of early-onset osteoporosis characterized by low trauma and spontaneous fractures during late pregnancy/lactation. Herein, we report areal BMD (aBMD) by DXA and volumetric BMD (vBMD), microarchitecture, and strength at the distal radius and tibia by HR-pQCT in 59 women with PLO-in comparison to both healthy premenopausal controls (n = 28) and premenopausal women with idiopathic osteoporotic fractures not associated with pregnancy/lactation (non-PLO IOP; n = 50). Women with PLO (aged 34 ± 6 yr) had a more severe clinical presentation than non-PLO IOP: 80% had vertebral and 92% had multiple fractures (p<.001). They had lower DXA aBMD at all sites vs Controls (all p<.001) and non-PLO IOP (all p<.05). By HR-pQCT, PLO ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-04T11:44:29.949Z","creation":"2026-05-08T03:10:49.417Z"},"accession":"S-EPMC12034093","cross_references":{"pubmed":["39423251"],"doi":["10.1093/jbmr/zjae167"]}}