{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Litvak Y"],"funding":["California Agricultural Experimental Station","NIAID NIH HHS","Public Health Service","USDA"],"pagination":["128-139.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12036633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Neonates are highly susceptible to infection with enteric pathogens, but the underlying mechanisms are not resolved. We show that neonatal chick colonization with Salmonella enterica serovar Enteritidis requires a virulence-factor-dependent increase in epithelial oxygenation, which drives pathogen expansion by aerobic respiration. Co-infection experiments with an Escherichia coli strain carrying an oxygen-sensitive reporter suggest that S. Enteritidis competes with commensal Enterobacteriaceae for oxygen. A combination of Enterobacteriaceae and spore-forming bacteria, but not colonization with either community alone, confers colonization resistance against S. Enteritidis in neonatal chicks, phenocopying germ-free mice associated with adult chicken microbiota. Combining spore-forming bacteria with a probiotic E. coli isolate protects germ-free mice from pathogen colonization, but the protection is lost when the ability to respire oxygen under micro-aerophilic conditions is genetically ablated in E. coli. These results suggest that commensal Enterobacteriaceae contribute to colonization resistance by competing with S. Enteritidis for oxygen, a resource critical for pathogen expansion."],"journal":["Cell host & microbe"],"pubmed_title":["Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition."],"pmcid":["PMC12036633"],"funding_grant_id":["R37 AI044170","AI112445","AI044170","R01 AI112445","R56 AI112949","AI060555","R01 AI044170","T32 AI060555","AI112949","R01 AI096528","AI096528","R01 AI112949"],"pubmed_authors":["Mon KKZ","Tsolis RM","Litvak Y","Byndloss MX","Zhu Y","Byndloss AJ","Alcantara MA","Bronner DN","Tiffany CR","Nguyen H","Faber F","Velazquez EM","Kutter L","Walker GT","Baumler AJ","Liou M","Zhou H","Chanthavixay G"],"additional_accession":[]},"is_claimable":false,"name":"Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition.","description":"Neonates are highly susceptible to infection with enteric pathogens, but the underlying mechanisms are not resolved. We show that neonatal chick colonization with Salmonella enterica serovar Enteritidis requires a virulence-factor-dependent increase in epithelial oxygenation, which drives pathogen expansion by aerobic respiration. Co-infection experiments with an Escherichia coli strain carrying an oxygen-sensitive reporter suggest that S. Enteritidis competes with commensal Enterobacteriaceae for oxygen. A combination of Enterobacteriaceae and spore-forming bacteria, but not colonization with either community alone, confers colonization resistance against S. Enteritidis in neonatal chicks, phenocopying germ-free mice associated with adult chicken microbiota. Combining spore-forming bacteria with a probiotic E. coli isolate protects germ-free mice from pathogen colonization, but the protection is lost when the ability to respire oxygen under micro-aerophilic conditions is genetically ablated in E. coli. These results suggest that commensal Enterobacteriaceae contribute to colonization resistance by competing with S. Enteritidis for oxygen, a resource critical for pathogen expansion.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-06-01T07:50:53.634Z","creation":"2025-06-27T03:05:14.32Z"},"accession":"S-EPMC12036633","cross_references":{"pubmed":["30629913"],"doi":["10.1016/j.chom.2018.12.003"]}}