biostudies-literatureHernaez RVeterans Administration Medical CenterUniverzita Karlova v PrazeCenter for Geosphere Dynamics, Charles UniversityNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSVA HSR&amp;DCenter for Innovations in Quality, Effectiveness and SafetyNational Cancer InstituteNCI NIH HHSNational Institutes of HealthCancer Prevention and Research Institute of Texas717-727https://www.ebi.ac.uk/biostudies/studies/S-EPMC12036733biostudies-literatureUnknown79(3)<h4>Background & aims</h4>Twenty-eight-day mortality ranges from 30-90% in patients with acute-on-chronic liver failure grades 2/3 (severe ACLF). Though liver transplantation (LT) has demonstrated a survival benefit, the scarcity of donor organs and uncertainty regarding post-LT mortality among patients with severe ACLF may cause hesitancy. We developed and externally validated a model to predict 1-year post-LT mortality in severe ACLF, called the Sundaram ACLF-LT-Mortality (SALT-M) score, and estimated the median length of stay (LoS) after LT (ACLF-LT-LoS).<h4>Methods</h4>In 15 LT centers in the US, we retrospectively identified a cohort of patients with severe ACLF transplanted between 2014-2019, followed up to Jan'2022. Candidate predictors included demographics, clinical and laboratoryJournal of hepatologyThe novel SALT-M score predicts 1-year post-transplant mortality in patients with severe acute-on-chronic liver failure.PMC12036733CIN 13-413U01 CA230997R01 CA186566NCI U01 CA230997U01 CA230690K08 DK124577P30 DK056338RP150587R01CA186566P30 DK 56338U01CA230690K08-DK124577U01 CA230694Gao JSundaram VKarvellas CJPatel PBoike JRLin MVMahmud NXue PRahimi RSWu TJalal PKFortune BEAl Attar AVyhmeister RJalan RShetty KSimonetto DAMulti-Organ Dysfunction and Evaluation for Liver Transplantation (MODEL) ConsortiumGarcia RHurtado MReddy VJou JHWinters ACYing XSimpson MAArtzner TLopez CRKhemichian SSacleux SCKriss MSLiu YKuo AHernaez RSalmastyan GKosari KCholankeril GMishra SParks MSaliba FMohamed IFlocco GKanwal FIm GYLindenmeyer CCThanneeru PCampbell BStein LLIzzy MCranford WfalseThe novel SALT-M score predicts 1-year post-transplant mortality in patients with severe acute-on-chronic liver failure.<h4>Background & aims</h4>Twenty-eight-day mortality ranges from 30-90% in patients with acute-on-chronic liver failure grades 2/3 (severe ACLF). Though liver transplantation (LT) has demonstrated a survival benefit, the scarcity of donor organs and uncertainty regarding post-LT mortality among patients with severe ACLF may cause hesitancy. We developed and externally validated a model to predict 1-year post-LT mortality in severe ACLF, called the Sundaram ACLF-LT-Mortality (SALT-M) score, and estimated the median length of stay (LoS) after LT (ACLF-LT-LoS).<h4>Methods</h4>In 15 LT centers in the US, we retrospectively identified a cohort of patients with severe ACLF transplanted between 2014-2019, followed up to Jan'2022. Candidate predictors included demographics, clinical and laboratory2023-01-01T00:00:00Z2023 Sep2025-07-03T03:04:35.031Z2025-07-03T03:04:35.031ZS-EPMC120367333731580910.1016/j.jhep.2023.05.028