{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ingle DJ"],"funding":["National Health and Medical Research Council"],"pagination":["e0100224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12039232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of human Q fever, <i>Coxiella burnetii</i>, represents the best-characterized member of this family. Coxiellaceae establish replicative niches within diverse host cells and rely on their host for survival, making them challenging to isolate and cultivate within a laboratory setting. Here, we describe a new genus within the Coxiellaceae family that has been previously shown to infect economically significant freshwater crayfish. Using culture-independent long-read metagenomics, we reconstructed the complete genome of this novel organism and demonstrate that the species previously referred to as Candid"],"journal":["mSphere"],"pubmed_title":["The complete genome sequence of the crayfish pathogen Candidatus &lt;i&gt;Paracoxiella cheracis&lt;/i&gt; n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family."],"pmcid":["PMC12039232"],"funding_grant_id":["GNT1194325","GNT1195210","GNT2010841"],"pubmed_authors":["Walsh CJ","Wick RR","Fiocchi E","Elliman J","Ingle DJ","Owens L","Stinear TP","Judd LM","Pretto T","Newton HJ","Basso A","Samuel GR","Davidovich N"],"additional_accession":[]},"is_claimable":false,"name":"The complete genome sequence of the crayfish pathogen Candidatus &lt;i&gt;Paracoxiella cheracis&lt;/i&gt; n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family.","description":"The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of human Q fever, <i>Coxiella burnetii</i>, represents the best-characterized member of this family. Coxiellaceae establish replicative niches within diverse host cells and rely on their host for survival, making them challenging to isolate and cultivate within a laboratory setting. Here, we describe a new genus within the Coxiellaceae family that has been previously shown to infect economically significant freshwater crayfish. Using culture-independent long-read metagenomics, we reconstructed the complete genome of this novel organism and demonstrate that the species previously referred to as Candid","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T07:48:17.399Z","creation":"2025-07-08T03:10:53.144Z"},"accession":"S-EPMC12039232","cross_references":{"pubmed":["40062866"],"doi":["10.1128/msphere.01002-24"]}}