biostudies-literatureZheng ZMedical Science and Technology Project of Zhejiang Provincial Health CommissionProject of NINGBO Leading Medical &amp; Health DisciplineNingbo Natural Science Foundatione0321318https://www.ebi.ac.uk/biostudies/studies/S-EPMC12040192biostudies-literatureUnknown20(4)<h4>Background</h4>Lymphoepithelial carcinoma (LEC) is a rare head and neck malignancy predominately treated with radiotherapy or surgery. However, comparative effectiveness studies, are lacking for non-nasopharyngeal head and neck LEC (HNLEC).<h4>Methods</h4>Patients diagnosed with non-nasopharyngeal HNLEC from 2000-2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Inverse probability of treatment weighting (IPTW) was used to balance baseline characteristics. Cancer-specific survival (CSS) was compared between surgery and radiotherapy groups using Kaplan-Meier analyses and Cox regression before and after IPTW adjustment.<h4>Results</h4>248 patients were included. Before IPTW adjustment, treatment modalities were not significantly associated with CSSPloS oneComparative effectiveness of surgery versus radiotherapy for non-nasopharyngeal head and neck lymphoepithelial carcinoma: An IPTW propensity score analysis.PMC120401922020KY8572021J2922022-F012023KY243Zheng ZWu JLiu KZhang HCao BBei YfalseComparative effectiveness of surgery versus radiotherapy for non-nasopharyngeal head and neck lymphoepithelial carcinoma: An IPTW propensity score analysis.<h4>Background</h4>Lymphoepithelial carcinoma (LEC) is a rare head and neck malignancy predominately treated with radiotherapy or surgery. However, comparative effectiveness studies, are lacking for non-nasopharyngeal head and neck LEC (HNLEC).<h4>Methods</h4>Patients diagnosed with non-nasopharyngeal HNLEC from 2000-2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Inverse probability of treatment weighting (IPTW) was used to balance baseline characteristics. Cancer-specific survival (CSS) was compared between surgery and radiotherapy groups using Kaplan-Meier analyses and Cox regression before and after IPTW adjustment.<h4>Results</h4>248 patients were included. Before IPTW adjustment, treatment modalities were not significantly associated with CSS2025-01-01T00:00:00Z20252025-07-04T03:05:58.408Z2025-07-04T03:05:58.408ZS-EPMC120401924029980810.1371/journal.pone.0321318