biostudies-literatureWang SSpace Utilization Project of China Manned Space ProgramShenzhen Science and Technology Innovation ProgramSpace Medical Experiment Project of China Manned Space ProgramChongming Project of the Heye Health Technology Co., LtdNational Natural Science Foundation of Chinae0314199https://www.ebi.ac.uk/biostudies/studies/S-EPMC12040201biostudies-literatureUnknown20(4)<h4>Background</h4>Postmenopausal osteoporosis (PMOP) is the most common type of osteoporosis. Numerous studies have shown that static magnetic fields (SMFs) can inhibit bone loss by regulating bone remodeling. However, there are currently no clinical studies on the treatment of osteoporosis with SMFs. This study aims to investigate the clinical therapeutic effects of moderate static magnetic fields (MMFs) on PMOP.<h4>Methods</h4>In this paper, we constructed MMF device using neodymium-iron-boron (NdFeB) materials. At the animal level, the effect of MMF exposure for 8 weeks on estrogen deficiency-induced bone loss was investigated by evaluating bone microstructure, mechanical properties, and bone conversion using ovariectomized (OVX) mice. Clinically, a single-blind randomized controlled sPloS oneModerate static magnetic fields prevent estrogen deficiency-induced bone loss: Evidence from ovariectomized mouse model and small sample size randomized controlled clinical trial.PMC12040201HY-I-202101HYZHXM01008YYWT-0901-EXP-04JCYJ2023080714415900452037007Yang JDuan LHu YGuo ZZhang HLuo CWei YBai XSun LZhang WLiao JFang YLi XWei MYang ZShang PCai CHuyan TWang SGong MLuo XChen SWu YZhou JfalseModerate static magnetic fields prevent estrogen deficiency-induced bone loss: Evidence from ovariectomized mouse model and small sample size randomized controlled clinical trial.<h4>Background</h4>Postmenopausal osteoporosis (PMOP) is the most common type of osteoporosis. Numerous studies have shown that static magnetic fields (SMFs) can inhibit bone loss by regulating bone remodeling. However, there are currently no clinical studies on the treatment of osteoporosis with SMFs. This study aims to investigate the clinical therapeutic effects of moderate static magnetic fields (MMFs) on PMOP.<h4>Methods</h4>In this paper, we constructed MMF device using neodymium-iron-boron (NdFeB) materials. At the animal level, the effect of MMF exposure for 8 weeks on estrogen deficiency-induced bone loss was investigated by evaluating bone microstructure, mechanical properties, and bone conversion using ovariectomized (OVX) mice. Clinically, a single-blind randomized controlled s2025-01-01T00:00:00Z20252025-07-04T03:06:05.479Z2025-07-04T03:06:05.479ZS-EPMC120402014029994210.1371/journal.pone.0314199