biostudies-literatureSkog RVetenskapsrådetRadiumhemmets ForskningsfonderForskningsrådet om Hälsa, Arbetsliv och VälfärdCancerfondene0322368https://www.ebi.ac.uk/biostudies/studies/S-EPMC12040239biostudies-literatureUnknown20(4)<h4>Background</h4>While previous literature has continuously demonstrated the negative effects of cancer and its treatment on fertility and sexuality, evidence-based interventions to alleviate fertility-related distress and sexual dysfunction are lacking. This study protocol describes the internal pilot study and randomized controlled trial of an internet-delivered psychoeducational intervention: Fex-Can 2.0. The primary objective is to determine efficacy of Fex-Can 2.0 in terms of reduction of fertility-related distress and sexual dysfunction at end of the 12-week intervention. The internal pilot study will assess feasibility of the study, determined according to pre-specified progression criteria and individual interviews.<h4>Methods</h4>The study has a randomized controlled design, witPloS oneAn internet-delivered psychoeducational intervention (Fex-Can 2.0) targeting fertility-related distress and sexual dysfunction in young adults diagnosed with cancer: Study protocol of a randomized controlled trial with an internal pilot phase.PMC12040239222311Pj2019-008381612722022-00832Wettergren LLampic CGorman JRSkog RBober SLOlsson EMGfalseAn internet-delivered psychoeducational intervention (Fex-Can 2.0) targeting fertility-related distress and sexual dysfunction in young adults diagnosed with cancer: Study protocol of a randomized controlled trial with an internal pilot phase.<h4>Background</h4>While previous literature has continuously demonstrated the negative effects of cancer and its treatment on fertility and sexuality, evidence-based interventions to alleviate fertility-related distress and sexual dysfunction are lacking. This study protocol describes the internal pilot study and randomized controlled trial of an internet-delivered psychoeducational intervention: Fex-Can 2.0. The primary objective is to determine efficacy of Fex-Can 2.0 in terms of reduction of fertility-related distress and sexual dysfunction at end of the 12-week intervention. The internal pilot study will assess feasibility of the study, determined according to pre-specified progression criteria and individual interviews.<h4>Methods</h4>The study has a randomized controlled design, wit2025-01-01T00:00:00Z20252025-07-08T03:10:48.836Z2025-07-08T03:10:48.836ZS-EPMC120402394030001010.1371/journal.pone.0322368