{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Y"],"funding":["Guangxi Medical University Undergraduate Education and Teaching Reform Project","Natural Science Foundation of Guangxi Province","Future Academic Star of Guangxi Medical University","China Undergraduate Innovation and Entrepreneurship Training Program","Guangxi Higher Education Undergraduate Teaching Reform Project","Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project","Guangxi Educational Science Planning Key Project"],"pagination":["e70017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12041129"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["SAE1, a key factor in tumour development, has not been thoroughly examined in pancreatic adenocarcinoma (PAAD), a cancer with high incidence and poor prognosis. We conducted a comprehensive study, integrating mRNA data, immunohistochemistry, CRISPR-modified cell line analysis and single-cell RNA sequencing to assess SAE1's role in PAAD. We also used ChIP-Seq to explore SAE1's transcriptional regulation and analysed clinical data, drug sensitivity and molecular docking models. SAE1 mRNA was significantly overexpressed in PAAD, with a substantial impact on cell proliferation and migration. Functional analyses linked SAE1 to cell cycle and DNA replication pathways, suggesting a role in PAAD development. Our study indicates that SAE1 may promote PAAD through cell cycle pathways, with FOXA1 pot"],"journal":["IET systems biology"],"pubmed_title":["SAE1 May Play a Pro-Carcinogenic Role in Pancreatic Adenocarcinoma: A Comprehensive Study Integrating Multiple Pieces of Evidence."],"pmcid":["PMC12041129"],"funding_grant_id":["2022JGA146","S202410598212","2023Z10","2022ZJY2791","GXZYA20230267","2025GXNSFAA069660","WLXSZX24118","GXZYA20230270"],"pubmed_authors":["Yu N","Chen G","Li Q","Li SD","Chi BT","Chen Y","Wu T","Meng LJ","Wei DM","Li MJ","Chen XJ","Huang SN","Ye YP"],"additional_accession":[]},"is_claimable":false,"name":"SAE1 May Play a Pro-Carcinogenic Role in Pancreatic Adenocarcinoma: A Comprehensive Study Integrating Multiple Pieces of Evidence.","description":"SAE1, a key factor in tumour development, has not been thoroughly examined in pancreatic adenocarcinoma (PAAD), a cancer with high incidence and poor prognosis. We conducted a comprehensive study, integrating mRNA data, immunohistochemistry, CRISPR-modified cell line analysis and single-cell RNA sequencing to assess SAE1's role in PAAD. We also used ChIP-Seq to explore SAE1's transcriptional regulation and analysed clinical data, drug sensitivity and molecular docking models. SAE1 mRNA was significantly overexpressed in PAAD, with a substantial impact on cell proliferation and migration. Functional analyses linked SAE1 to cell cycle and DNA replication pathways, suggesting a role in PAAD development. Our study indicates that SAE1 may promote PAAD through cell cycle pathways, with FOXA1 pot","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan-Dec","modification":"2025-06-25T03:06:03.297Z","creation":"2025-06-25T03:06:03.297Z"},"accession":"S-EPMC12041129","cross_references":{"pubmed":["40302186"],"doi":["10.1049/syb2.70017"]}}