{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["132(9)"],"submitter":["Groen-van Schooten TS"],"pubmed_abstract":["<h4>Background</h4>Gastric cancer (GC) patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in previous large-scale multi-omic studies that have identified clinically relevant subgroups. The LEGACY study aimed to profile the molecular and immunological features of GCs from EU and LATAM countries.<h4>Methods</h4>Tumor biopsies from 95 EU and 56 LATAM GCs were profiled with immunohistochemistry (CD3, CD8, FOXP3, PD-L1, MSI and HER2), Nanostring mRNA expression analyses, and microbiome sequencing.<h4>Results</h4>Immune profiling identified four distinct immune clusters: a T cell dominant cluster with enriched activation pathways, a macrophage dominant cluster and an immune excluded microenvironment which were equally distributed among the countries."],"journal":["British journal of cancer"],"pagination":["783-792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12041472"],"repository":["biostudies-literature"],"pubmed_title":["Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence."],"pmcid":["PMC12041472"],"pubmed_authors":["Boggino H","Costa A","Roa JC","Alsina M","Ruiz-Pace F","Freile B","Lino-Silva L","Cabeza-Segura M","Caballero C","Dientsmann R","Martinez-Ciarpaglini C","Owen G","Esteso F","Pereira R","Gauna C","Lordick F","Fleitas T","Fernandez-Figueroa EA","Ruiz-Garcia E","Santos-Antunes J","Cantero D","Ferreira RM","Jimenez-Marti E","Groen-van Schooten TS","Carbonell-Asins JA","Latorre G","Figueiredo C","Riquelme E","Cervantes A","Miralles A","Riquelme A","Pouw RE","Carneiro F","Hernandez-Guerrero AI","Garrido M","Villagrasa R","Derks S","Barros R","Diez Garcia M","O Connor J","Farres J"],"additional_accession":[]},"is_claimable":false,"name":"Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence.","description":"<h4>Background</h4>Gastric cancer (GC) patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in previous large-scale multi-omic studies that have identified clinically relevant subgroups. The LEGACY study aimed to profile the molecular and immunological features of GCs from EU and LATAM countries.<h4>Methods</h4>Tumor biopsies from 95 EU and 56 LATAM GCs were profiled with immunohistochemistry (CD3, CD8, FOXP3, PD-L1, MSI and HER2), Nanostring mRNA expression analyses, and microbiome sequencing.<h4>Results</h4>Immune profiling identified four distinct immune clusters: a T cell dominant cluster with enriched activation pathways, a macrophage dominant cluster and an immune excluded microenvironment which were equally distributed among the countries.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-08T19:50:01.425Z","creation":"2025-07-06T03:05:50.007Z"},"accession":"S-EPMC12041472","cross_references":{"pubmed":["40113862"],"doi":["10.1038/s41416-025-02979-6"]}}