biostudies-literatureUnknown12(1)Umpierrez GE<b>Background:</b> The association between falls or fall-related fractures and hypoglycemia in people with type 2 diabetes is well established. Insulin treatment is associated with an increased risk of hypoglycemia, which is compounded in people of older age, but the risk is lower with longer-acting vs intermediate- or long-acting basal insulin analogs. <b>Objective:</b> To examine healthcare resource utilization and costs related to falls/fractures in people with type 2 diabetes treated with the longer-acting basal insulin Gla-300 (insulin glargine 300 U/mL) vs long-acting basal insulins (insulin glargine 100 U/mL or insulin detemir)/neutral protamine Hagedorn (NPH). <b>Methods:</b> This retrospective study of Optum's de-identified Clinformatics® Data Mart Database compared data for peoplJournal of health economics and outcomes research171-183https://www.ebi.ac.uk/biostudies/studies/S-EPMC12043012biostudies-literatureHealthcare Resource Utilization and Costs Related to Falls and Fractures Among People With Type 2 Diabetes Receiving Basal Insulin: The FRAGILE Study.PMC12043012Li XPreblick RPandya NUmpierrez GEPogge EKGill JfalseHealthcare Resource Utilization and Costs Related to Falls and Fractures Among People With Type 2 Diabetes Receiving Basal Insulin: The FRAGILE Study.<b>Background:</b> The association between falls or fall-related fractures and hypoglycemia in people with type 2 diabetes is well established. Insulin treatment is associated with an increased risk of hypoglycemia, which is compounded in people of older age, but the risk is lower with longer-acting vs intermediate- or long-acting basal insulin analogs. <b>Objective:</b> To examine healthcare resource utilization and costs related to falls/fractures in people with type 2 diabetes treated with the longer-acting basal insulin Gla-300 (insulin glargine 300 U/mL) vs long-acting basal insulins (insulin glargine 100 U/mL or insulin detemir)/neutral protamine Hagedorn (NPH). <b>Methods:</b> This retrospective study of Optum's de-identified Clinformatics® Data Mart Database compared data for peopl2025-01-01T00:00:00Z20252026-03-13T10:32:57.762Z2025-07-08T03:12:26.283ZS-EPMC120430124030926410.36469/001c.133274