{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["the Guangdong Basic and Applied Basic Research Foundation","National Natural Science Foundation of China"],"pagination":["73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12044087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Optical manipulation and detection of single molecules, such as biomolecules and bacterial viruses, are crucial in single-molecule mechanics and biosensing. The interaction between light and individual molecules is weak due to the size of biomolecules (≤ 10 nm) being significantly smaller than the wavelength (λ) of light. This limitation results in a reduced optical gradient force and diminished detection sensitivity of light on biomolecules. To overcome this challenge, we propose a single-molecule trapping and sensing method that utilizes whisper-gallery mode (WGM) coupled photonic nanojets (PNJs). Our theoretical analysis demonstrates that a focused beam with a waist radius of λ/6 can be generated by WGM-coupled PNJs. By harnessing this sub-diffraction-limit focused beam, we create a sta"],"journal":["Discover nano"],"pubmed_title":["Single-molecule manipulation and detection by WGM-coupled photonic nanojets."],"pmcid":["PMC12044087"],"funding_grant_id":["2023A1515030143","62422505","12474431","62305132"],"pubmed_authors":["Li H","Li Y","He T","Zhang Y","Wu T","Gong Z"],"additional_accession":[]},"is_claimable":false,"name":"Single-molecule manipulation and detection by WGM-coupled photonic nanojets.","description":"Optical manipulation and detection of single molecules, such as biomolecules and bacterial viruses, are crucial in single-molecule mechanics and biosensing. The interaction between light and individual molecules is weak due to the size of biomolecules (≤ 10 nm) being significantly smaller than the wavelength (λ) of light. This limitation results in a reduced optical gradient force and diminished detection sensitivity of light on biomolecules. To overcome this challenge, we propose a single-molecule trapping and sensing method that utilizes whisper-gallery mode (WGM) coupled photonic nanojets (PNJs). Our theoretical analysis demonstrates that a focused beam with a waist radius of λ/6 can be generated by WGM-coupled PNJs. By harnessing this sub-diffraction-limit focused beam, we create a sta","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:39.88Z","creation":"2025-07-10T03:08:39.88Z"},"accession":"S-EPMC12044087","cross_references":{"pubmed":["40304933"],"doi":["10.1186/s11671-025-04253-3"]}}