{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["116(5)"],"submitter":["Matsubara N"],"funding":["Janssen Japan"],"pubmed_abstract":["Advanced/metastatic urothelial cancer (a/m UC) still has a poor prognosis despite the recent medical advances. Recent studies demonstrated that fibroblast growth factor receptor (FGFR) gene alterations (GAs) may be driver genes for UC; however, the proportion of UC genetic panel testing in Japan remains low. We clarified the proportion of patients with FGFR2/3 GAs, treatment patterns, and clinical outcomes in a/m UC patients in Japan. This study was a descriptive epidemiological study using the MONSTAR-SCREEN database, and 138 patients with a/m UC were evaluated. The primary endpoint was the proportion of patients with FGFR2/3 GAs. The secondary endpoints included treatment patterns, clinical outcomes, genomic status before and after treatment, etc. The proportion of FGFR GA-positive patie"],"journal":["Cancer science"],"pagination":["1424-1432"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12044656"],"repository":["biostudies-literature"],"pubmed_title":["FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR-SCREEN Database Study."],"pmcid":["PMC12044656"],"pubmed_authors":["Yoshida M","Tatematsu Y","Nonomura N","Osawa T","Nishimoto K","Eto M","Iwahori T","Murota M","Oya M","Matsubara N","Abe T","Nakano Y","Tsuchiya H"],"additional_accession":[]},"is_claimable":false,"name":"FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR-SCREEN Database Study.","description":"Advanced/metastatic urothelial cancer (a/m UC) still has a poor prognosis despite the recent medical advances. Recent studies demonstrated that fibroblast growth factor receptor (FGFR) gene alterations (GAs) may be driver genes for UC; however, the proportion of UC genetic panel testing in Japan remains low. We clarified the proportion of patients with FGFR2/3 GAs, treatment patterns, and clinical outcomes in a/m UC patients in Japan. This study was a descriptive epidemiological study using the MONSTAR-SCREEN database, and 138 patients with a/m UC were evaluated. The primary endpoint was the proportion of patients with FGFR2/3 GAs. The secondary endpoints included treatment patterns, clinical outcomes, genomic status before and after treatment, etc. The proportion of FGFR GA-positive patie","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-03T02:42:12.1Z","creation":"2025-07-06T03:05:59.556Z"},"accession":"S-EPMC12044656","cross_references":{"pubmed":["39933925"],"doi":["10.1111/cas.70000"]}}