biostudies-literatureMohr KJohannes Gutenberg University MainzBayer AGFederal Ministry of Education and Research334-342https://www.ebi.ac.uk/biostudies/studies/S-EPMC12045087biostudies-literatureUnknown11(3)<h4>Aims</h4>Patients surviving acute pulmonary embolism (PE) necessitate long-term treatment and follow-up. We estimated, the chronic economic impact of PE on the German healthcare system.<h4>Methods and results</h4>We calculated the direct cost of illness during the first year after discharge for the index PE, analysing data from a multicentre prospective cohort study in Germany. Main and accompanying readmission diagnoses were used to calculate DRG-based hospital reimbursements; anticoagulation costs were estimated from the exact treatment duration and each drug's unique national identifier; and outpatient post-PE care costs from guidelines-recommended algorithms and national reimbursement catalogues. Of 1017 patients enrolled at 17 centres, 958 (94%) completed ≥3-month follow-up; of thEuropean heart journal. Quality of care & clinical outcomesEstimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study.PMC12045087006_PH/Schau(32690)FOCUS1725701EO100301EO1503Valerio LWachter RTrudzinski FNeusius TLeuchte HHRosenkranz SHoltz IKonstantinides SVMavromanoli ACKaberich AKlok FABinder HFOCUS InvestigatorsOtto SHobohm LHeier EMPohl CEmge-Rossa DThabaret KOpitz CMartin NHalank MTausche KEwert RKeller KHorn AFischer BSchuler KBerger PLandmesser ASalkic AHoeper MMSeyfarth HJMildenberger PKaier KTayler SMeyer FJGerhardt FSchroder BFistera DHennig ABarton JSentler CBarco SMohr KGrunig EGrgic AFaehling MMayer EGun SAbele CGeistert SBruch LWilkens HNeurohr CJakel DHellenkamp KHeld MGeorge URink TSchmidtmann IEgenlauf BFreise JFarmakis ITPieper JGhofrani HABressem IChristodoulou KCSchmidt KHWild PSBlaich BRudolph JSchulte MBecker DfalseEstimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study.<h4>Aims</h4>Patients surviving acute pulmonary embolism (PE) necessitate long-term treatment and follow-up. We estimated, the chronic economic impact of PE on the German healthcare system.<h4>Methods and results</h4>We calculated the direct cost of illness during the first year after discharge for the index PE, analysing data from a multicentre prospective cohort study in Germany. Main and accompanying readmission diagnoses were used to calculate DRG-based hospital reimbursements; anticoagulation costs were estimated from the exact treatment duration and each drug's unique national identifier; and outpatient post-PE care costs from guidelines-recommended algorithms and national reimbursement catalogues. Of 1017 patients enrolled at 17 centres, 958 (94%) completed ≥3-month follow-up; of th2025-01-01T00:00:00Z2025 May2025-07-08T03:12:48.807Z2025-07-08T03:12:48.807ZS-EPMC120450873895090010.1093/ehjqcco/qcae050