biostudies-literatureAlduhayh SIntramural NIH HHSFondation ARC pour la Recherche sur le CancerInstitut National Du Cancer (INCa)World Health OrganizationNCATS NIH HHSCancer Research UKInstitut National Du CancerNIA NIH HHSNIEHS NIH HHSNIAID NIH HHSNHLBI NIH HHSNIDDK NIH HHSNHGRI NIH HHSNCI NIH HHSFondation ARC pour la Recherche sur le Cancer (ARC)NIH HHSWHI NIH HHS722-736https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046324biostudies-literatureUnknown34(5)<h4>Background</h4>The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with the risk of overall and early-onset colorectal cancer.<h4>Methods</h4>Genome-wide association study summary statistical data were used to identify genetic variants associated with allergic diseases (Nvariants = 65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, and eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases = 52,775 cases) and early-onset colorectal cancer (Ncases = 6,1Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyAssociation of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study.PMC12046324K05 CA154337P01 CA087969U01 CA074783U01 CA176726P01 CA196569K05 CA152715R01 CA197350KL2 TR0004212020-076R21 CA191312U01 CA152753P30 CA014089K01 AI153558R01 CA151993R01 CA072520R01 CA076366P30 CA076292R37 CA054281U01 HG004438P30 CA006973RF2019020858775N92021D0000175N92021D0000275N92021D00003R01 CA20737175N92021D00004R01 CA137178U01 CA12283975N92021D00005R01 CA081488R01 CA042182P01 CA033619001P30 CA016058R01 CA063464R01 CA067941R01 CA242218R01 CA136726UM1 CA186107U01 CA086308R35 CA197735U01 CA167552U01 HG004446R01 CA048998T32 ES013678U01 CA167551Z01 CP010200R01 CA189184HHSN268201700006CUM1 CA167552U01 CA067941HHSN268201200008IP30 DK034987S10 OD028685C18281/A29019P01 CA055075R01 CA097325R01 CA059045HHSN268201200008CU01 CA164930R01 CA201407U19 CA148107P30 CA015704U24 CA074794U01 CA074794R01 CA143237U01 CA206110R01 CA066635R03 CA153323R01 CA273198U10 CA037429R01 CA248857UM1 CA182883U01 AG018033Zhu ZHuang WYSeveri GPlatz EAPhipps AICastellvi-Bel SMurphy NGrant RCLi CIJiang XVincent EEHaycock PUlrich CMGunter MJBuchanan DDPearlman RChan ATVan Guelpen BZheng WAlduhayh SKweon SSLi LOgino SLaskar RSGruber SBFigueiredo JCDimou NBrenner HConstantinescu AEPellatt AfalseAssociation of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study.<h4>Background</h4>The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with the risk of overall and early-onset colorectal cancer.<h4>Methods</h4>Genome-wide association study summary statistical data were used to identify genetic variants associated with allergic diseases (Nvariants = 65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, and eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases = 52,775 cases) and early-onset colorectal cancer (Ncases = 6,12025-01-01T00:00:00Z2025 May2026-06-02T20:54:50.782Z2025-07-06T03:05:48.113ZS-EPMC120463243998269410.1158/1055-9965.EPI-24-0970