biostudies-literatureYamaguchi TNNational Cancer Institute (NCI)DOD Prostate Cancer Research Program (PCRP)NIEHS NIH HHSNHGRI NIH HHSNational Cancer InstituteNCI NIH HHSDOD Prostate Cancer Research Program988-1017https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046336biostudies-literatureUnknown15(5)<h4>Significance</h4>This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.Cancer discoveryThe Germline and Somatic Origins of Prostate Cancer Heterogeneity.PMC12046336R01 CA270108U01 HG009080W81XWH2210751W81XWH2210247R01CA270108U24 CA248265R01 CA251555R01 HG006399U2CACA271894P30 CA016042R01 CA245294R01 HG011345R01 ES029929R01 CA227466U2C CA271894R01 CA227237Houlahan KEKurganovs NLalansingh CMClarkson MJFox NSHovington HRamanand SGCorcoran NMMani RSLiu LYFraser MO'Connor ELivingstone JBornman RMSPope BJHayes VMMcCoy PJChan EKFJovelin RShiah YJPark DJCostello AJYuan JProkopec SDRyan ASendorek DHSGusev APasaniuc BLesurf Rvan der Kwast TJaratlerdsiri Wvan Riet JLacombe LEspiritu SMGJiang JKishan AUStricker PDCmero MHe HHSabelnykova VMcPherson JDWakefield MMcintosh LOrain MJung CHBhandari VReimand JHovens CMTaraszka KSchwarz TPicard VHung RJMangiola SHeisler LEChow KSalcedo AMutambirwa SBAPeters JSStuchbery RSeo JHPapenfuss ATBristow RGBell CWaszak SMTetu BYamaguchi TNZhu HLonie AFoucal ABergeron ASietsma Penington JHuang VFreedman MLZaitlen NLolkema MPPomerantz MMKerger MFradet YBoutros PCNguyen AWeischenfeldt JGeorgeson PfalseThe Germline and Somatic Origins of Prostate Cancer Heterogeneity.<h4>Significance</h4>This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.2025-01-01T00:00:00Z2025 May2026-06-02T12:04:22.938Z2025-07-08T03:13:47.672ZS-EPMC120463363994574410.1158/2159-8290.CD-23-0882