{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["147(17)"],"submitter":["Gorai M"],"pubmed_abstract":["A highly active bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene complex and a basic 2-iminopyridine subunit allows for copper hydride chemistry under low H<sub>2</sub> pressure, achieving efficient catalysis reaching 1 bar (balloon pressure). The bifunctional catalyst tolerates a remarkable variety of functional groups in catalytic alkyne semihydrogenations. Furthermore, this catalyst design gives rise to a high reactivity that allows for the catalytic hydrogenation of α,β-unsaturated amides (a substrate class hitherto unreactive in copper hydride catalysis) at a low H<sub>2</sub> pressure for the first time. In this manner, late-stage modification and isotope labeling of α,β-unsaturated amides, common subunits in biologically active compounds, can be realized throug"],"journal":["Journal of the American Chemical Society"],"pagination":["14481-14490"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046561"],"repository":["biostudies-literature"],"pubmed_title":["Broadly Applicable Copper(I)-Catalyzed Alkyne Semihydrogenation and Hydrogenation of α,β-Unsaturated Amides Enabled by Bifunctional Iminopyridine Ligands."],"pmcid":["PMC12046561"],"pubmed_authors":["Ruffer T","Dielmann F","Teichert JF","Gorai M","Franzen JH","Rotering P"],"additional_accession":[]},"is_claimable":false,"name":"Broadly Applicable Copper(I)-Catalyzed Alkyne Semihydrogenation and Hydrogenation of α,β-Unsaturated Amides Enabled by Bifunctional Iminopyridine Ligands.","description":"A highly active bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene complex and a basic 2-iminopyridine subunit allows for copper hydride chemistry under low H<sub>2</sub> pressure, achieving efficient catalysis reaching 1 bar (balloon pressure). The bifunctional catalyst tolerates a remarkable variety of functional groups in catalytic alkyne semihydrogenations. Furthermore, this catalyst design gives rise to a high reactivity that allows for the catalytic hydrogenation of α,β-unsaturated amides (a substrate class hitherto unreactive in copper hydride catalysis) at a low H<sub>2</sub> pressure for the first time. In this manner, late-stage modification and isotope labeling of α,β-unsaturated amides, common subunits in biologically active compounds, can be realized throug","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-13T03:04:35.685Z","creation":"2025-07-13T03:04:35.685Z"},"accession":"S-EPMC12046561","cross_references":{"pubmed":["40239054"],"doi":["10.1021/jacs.5c01339"]}}