biostudies-literatureUnknown147(17)Gorai MA highly active bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene complex and a basic 2-iminopyridine subunit allows for copper hydride chemistry under low H₂ pressure, achieving efficient catalysis reaching 1 bar (balloon pressure). The bifunctional catalyst tolerates a remarkable variety of functional groups in catalytic alkyne semihydrogenations. Furthermore, this catalyst design gives rise to a high reactivity that allows for the catalytic hydrogenation of α,β-unsaturated amides (a substrate class hitherto unreactive in copper hydride catalysis) at a low H₂ pressure for the first time. In this manner, late-stage modification and isotope labeling of α,β-unsaturated amides, common subunits in biologically active compounds, can be realized througJournal of the American Chemical Society14481-14490https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046561biostudies-literatureBroadly Applicable Copper(I)-Catalyzed Alkyne Semihydrogenation and Hydrogenation of α,β-Unsaturated Amides Enabled by Bifunctional Iminopyridine Ligands.PMC12046561Ruffer TDielmann FTeichert JFGorai MFranzen JHRotering PfalseBroadly Applicable Copper(I)-Catalyzed Alkyne Semihydrogenation and Hydrogenation of α,β-Unsaturated Amides Enabled by Bifunctional Iminopyridine Ligands.A highly active bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene complex and a basic 2-iminopyridine subunit allows for copper hydride chemistry under low H₂ pressure, achieving efficient catalysis reaching 1 bar (balloon pressure). The bifunctional catalyst tolerates a remarkable variety of functional groups in catalytic alkyne semihydrogenations. Furthermore, this catalyst design gives rise to a high reactivity that allows for the catalytic hydrogenation of α,β-unsaturated amides (a substrate class hitherto unreactive in copper hydride catalysis) at a low H₂ pressure for the first time. In this manner, late-stage modification and isotope labeling of α,β-unsaturated amides, common subunits in biologically active compounds, can be realized throug2025-01-01T00:00:00Z2025 Apr2025-07-13T03:04:35.685Z2025-07-13T03:04:35.685ZS-EPMC120465614023905410.1021/jacs.5c01339