biostudies-literatureUnknown11(3)Laudani C<h4>Background and aims</h4>Multiple anti-inflammatory drugs have been tested for secondary prevention after myocardial infarction (MI), giving mixed results and questioning the efficacy of anti-inflammatory therapy. No head-to-head comparisons between anti-inflammatory drugs have been performed. This study aimed to compare the efficacy and safety of anti-inflammatory drugs for secondary prevention after MI and the relative merits of specific drugs and administration strategies.<h4>Methods and results</h4>Randomized trials of anti-inflammatory therapy for secondary prevention after MI were identified. Primary efficacy and safety endpoints were trial-defined major adverse cardiovascular events (MACEs) and serious adverse events. Secondary endpoints included all-cause death, individual MACE European heart journal. Cardiovascular pharmacotherapy218-229https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046582biostudies-literatureA pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study.PMC12046582Laudani CCapodanno DGreco AGiacoppo DOcchipinti GSpagnolo MfalseA pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study.<h4>Background and aims</h4>Multiple anti-inflammatory drugs have been tested for secondary prevention after myocardial infarction (MI), giving mixed results and questioning the efficacy of anti-inflammatory therapy. No head-to-head comparisons between anti-inflammatory drugs have been performed. This study aimed to compare the efficacy and safety of anti-inflammatory drugs for secondary prevention after MI and the relative merits of specific drugs and administration strategies.<h4>Methods and results</h4>Randomized trials of anti-inflammatory therapy for secondary prevention after MI were identified. Primary efficacy and safety endpoints were trial-defined major adverse cardiovascular events (MACEs) and serious adverse events. Secondary endpoints included all-cause death, individual MACE 2025-01-01T00:00:00Z2025 May2025-06-25T03:06:36.449Z2025-06-25T03:06:36.449ZS-EPMC120465823975638610.1093/ehjcvp/pvae100