biostudies-literatureChen LGeneral Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Nature Science Foundation of ChinaNational Key Research and Development Program of China223https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046914biostudies-literatureUnknown16(1)<h4>Background</h4>Periodontitis is a chronic inflammatory disease and macrophages play a pivotal role in the progression of periodontitis. Mesenchymal stem cells (MSCs) have emerged as potential therapeutic agents for the treatment of periodontitis due to their immunomodulatory properties and capacity for tissue regeneration. Compared to conventionally derived MSCs, induced pluripotent stem cell-derived MSCs (iMSCs) offer distinct advantages as promising candidates for MSC-based therapies, owing to their non-invasive acquisition methods and virtually unlimited availability. This study aims to investigate the effects and mechanisms of iMSCs in modulating macrophage polarization and alleviating periodontitis-related alveolar bone loss.<h4>Methods</h4>iMSCs were generated from iPSCs and charStem cell research & therapyInduced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis.PMC12046914823709562023YFC25063008240110532371533Liu YLiu JLi YYu CZhang YChen LMa YCai YLuan QGeng YCao PfalseInduced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis.<h4>Background</h4>Periodontitis is a chronic inflammatory disease and macrophages play a pivotal role in the progression of periodontitis. Mesenchymal stem cells (MSCs) have emerged as potential therapeutic agents for the treatment of periodontitis due to their immunomodulatory properties and capacity for tissue regeneration. Compared to conventionally derived MSCs, induced pluripotent stem cell-derived MSCs (iMSCs) offer distinct advantages as promising candidates for MSC-based therapies, owing to their non-invasive acquisition methods and virtually unlimited availability. This study aims to investigate the effects and mechanisms of iMSCs in modulating macrophage polarization and alleviating periodontitis-related alveolar bone loss.<h4>Methods</h4>iMSCs were generated from iPSCs and char2025-01-01T00:00:00Z2025 May2025-06-25T03:06:28.573Z2025-06-25T03:06:28.573ZS-EPMC120469144031706410.1186/s13287-025-04327-0