{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(1)"],"submitter":["Liu M"],"pubmed_abstract":["<h4>Background</h4>Bladder cancer (BCa) is the most prevalent malignancy of the urinary system. Aberrant glycosylation, driven by specific glycosyltransferases (GTs), plays a pivotal role in various carcinogenic processes. However, the role of GTs-related glycobiomarkers and their underlying mechanisms in BCa remain poorly understood.<h4>Methods</h4>A diagnostic model based on GTs was constructed and validated using multiple bioinformatics tools. The diagnostic and prognostic value, biological functions and potential targeted drugs were assessed using R packages, K-M plotter and molecular docking. The functional impact and mechanism of ALG3 in BCa were investigated through functional assays, RNA sequencing, immunoprecipitation, and lectin pull down assays.<h4>Results</h4>A diagnostic model"],"journal":["European journal of medical research"],"pagination":["353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12046919"],"repository":["biostudies-literature"],"pubmed_title":["ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway."],"pmcid":["PMC12046919"],"pubmed_authors":["Li S","Liu M","Zhang J","Jiang W","Zheng Q","Yan Y","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway.","description":"<h4>Background</h4>Bladder cancer (BCa) is the most prevalent malignancy of the urinary system. Aberrant glycosylation, driven by specific glycosyltransferases (GTs), plays a pivotal role in various carcinogenic processes. However, the role of GTs-related glycobiomarkers and their underlying mechanisms in BCa remain poorly understood.<h4>Methods</h4>A diagnostic model based on GTs was constructed and validated using multiple bioinformatics tools. The diagnostic and prognostic value, biological functions and potential targeted drugs were assessed using R packages, K-M plotter and molecular docking. The functional impact and mechanism of ALG3 in BCa were investigated through functional assays, RNA sequencing, immunoprecipitation, and lectin pull down assays.<h4>Results</h4>A diagnostic model","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-05-25T03:09:50.986Z","creation":"2025-07-08T03:13:44.413Z"},"accession":"S-EPMC12046919","cross_references":{"pubmed":["40312703"],"doi":["10.1186/s40001-025-02604-5"]}}