{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Polkoff KM"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Institutes of Health Office of the Director","NIAMS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["496-509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12051919"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(5)"],"pubmed_abstract":["Cells expressing leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) play a pivotal role in homeostasis, repair, and regeneration in multiple organs, including skin and gastrointestinal tract, but little is known about their role in the lung. Findings from mice, a widely used animal model, suggest that lung LGR5 expression differs from that of humans. In this work, using a new transgenic pig model, we identify two main populations of LGR5<sup>+</sup> cells in the lung that are conserved in human but not mouse lungs. Using RNA sequencing, three-dimensional imaging, and organoid models, we determine that in the fetal lung, epithelial LGR5 expression is transient in a subpopulation of SOX9<sup>+</sup>/ETV5<sup>+</sup>/SFTPC<sup>+</sup> progenitor lung tip cells. In contrast, ep"],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis."],"pmcid":["PMC12051919"],"funding_grant_id":["R21 OD019738","T34GM131947","F31AR077423","F31 AR077423","T34 GM131947","R21OD019738","P30 DK034987","P30DK034987"],"pubmed_authors":["Gleason K","Moatti A","Murphy Y","Murthy PK","Tata PR","Lampe R","Carter A","Piedrahita JA","Edwards L","Chung J","Simon JM","Gupta NK","Greenbaum A","Polkoff KM","Tata A"],"additional_accession":[]},"is_claimable":false,"name":"Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis.","description":"Cells expressing leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) play a pivotal role in homeostasis, repair, and regeneration in multiple organs, including skin and gastrointestinal tract, but little is known about their role in the lung. Findings from mice, a widely used animal model, suggest that lung LGR5 expression differs from that of humans. In this work, using a new transgenic pig model, we identify two main populations of LGR5<sup>+</sup> cells in the lung that are conserved in human but not mouse lungs. Using RNA sequencing, three-dimensional imaging, and organoid models, we determine that in the fetal lung, epithelial LGR5 expression is transient in a subpopulation of SOX9<sup>+</sup>/ETV5<sup>+</sup>/SFTPC<sup>+</sup> progenitor lung tip cells. In contrast, ep","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-05T11:49:34.71Z","creation":"2026-05-16T03:13:34.239Z"},"accession":"S-EPMC12051919","cross_references":{"pubmed":["39499850"],"doi":["10.1165/rcmb.2024-0040OC","10.1165/rcmb.2024-0040oc"]}}