{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren P"],"funding":["NHLBI NIH HHS"],"pagination":["260-276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12053597"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["<h4>Background</h4>Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults.<h4>Methods</h4>We analyzed single-cell transcriptomes of aortic SMCs from adult mice to determine basal states and changes after disrupting TGFβ (transforming growth factor-β) signaling necessary for aortic homeostasis.<h4>Results</h4>A minority of Myh11 lineage-marked SMCs differentially expressed genes suggestive of embryological origin. Additional analyses in Nkx2-5 and Wnt1 lineage-marked SMCs derived from cardiac and neural crest progenitors, respectively, showed both lineages contributed to a major common cluster and each lineage to a minor distinct cluster. Common cluster SMCs extended from root to arch, cardiac "],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Heterogeneous Cardiac-Derived and Neural Crest-Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption."],"pmcid":["PMC12053597"],"funding_grant_id":["R01 HL146723","R01 HL152197","P01 HL107205"],"pubmed_authors":["Li G","Li W","Hassab AHM","Tellides G","Ren P","Jiang B","Assi R"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous Cardiac-Derived and Neural Crest-Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption.","description":"<h4>Background</h4>Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults.<h4>Methods</h4>We analyzed single-cell transcriptomes of aortic SMCs from adult mice to determine basal states and changes after disrupting TGFβ (transforming growth factor-β) signaling necessary for aortic homeostasis.<h4>Results</h4>A minority of Myh11 lineage-marked SMCs differentially expressed genes suggestive of embryological origin. Additional analyses in Nkx2-5 and Wnt1 lineage-marked SMCs derived from cardiac and neural crest progenitors, respectively, showed both lineages contributed to a major common cluster and each lineage to a minor distinct cluster. Common cluster SMCs extended from root to arch, cardiac ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-11T05:37:50.027Z","creation":"2026-06-11T03:08:26.238Z"},"accession":"S-EPMC12053597","cross_references":{"pubmed":["39697172"],"doi":["10.1161/atvbaha.124.321706","10.1161/ATVBAHA.124.321706"]}}