{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harvie HS"],"funding":["NICHD NIH HHS"],"pagination":["1887-1896"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12053799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["333(21)"],"pubmed_abstract":["<h4>Importance</h4>Mixed urinary incontinence, which includes both stress and urgency urinary incontinence, adversely affects quality of life and can be difficult to manage. Studies comparing procedural-based treatments for mixed urinary incontinence are lacking.<h4>Objective</h4>To determine whether intradetrusor onabotulinumtoxinA is more effective than midurethral sling for the treatment of mixed urinary incontinence in females.<h4>Design, setting, and participants</h4>Randomized, superiority trial involving females (aged ≥21 years) with moderate to severe bother from both stress and urgency urinary incontinence who had unsuccessful conservative treatments and oral medications. The study was conducted at 7 US sites with enrollment between July 2020 and September 2022; the last date of f"],"journal":["JAMA"],"pubmed_title":["Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence: The MUSA Randomized Clinical Trial."],"pmcid":["PMC12053799"],"funding_grant_id":["UG1 HD069013","U10 HD041267","UG1 HD041261","UG1 HD054241","UG1 HD069010","U24 HD069031","UG1 HD054214","UG1 HD069006"],"pubmed_authors":["Siddiqui N","Burdekin K","Nager C","Lippmann Q","Ackenbom M","Baranski L","Visco A","Wai CY","Brubaker L","Arya LA","Mackinnon L","Patel S","Tan-Kim J","Meyer I","National Institute of Child Health and Human Development Pelvic Floor Disorders Network","Wohlrab K","Menefee SA","Richter HE","Lukacz E","Bruton Y","Escher A","Zazueta-Damian G","Ellington D","Diwadkar G","Rhodes E","Kennedy Z","Amundsen CL","Myers D","Gantz M","Korbly N","Yu S","Carper B","Hampton BS","Mazloomdoost D","Chermansky CJ","Sung VW","Huitema C","Newman D","Thomas S","Bonidie M","Guerreo M","Rahn DD","Rodriguez-Ponciano D","Rardin C","Zyczynski H","Medrano R","Carberry C","Moalli P","Barden L","Smith A","Giugale L","Herrala K","Brenizer T","Veera S","Alperin M","Schaffer JI","Florian-Rodriguez M","Bradley M","Burris A","Weidner A","Harvie HS","Balgobin S","Hicks C","Schmitt A","Durst R","Andy U"],"additional_accession":[]},"is_claimable":false,"name":"Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence: The MUSA Randomized Clinical Trial.","description":"<h4>Importance</h4>Mixed urinary incontinence, which includes both stress and urgency urinary incontinence, adversely affects quality of life and can be difficult to manage. Studies comparing procedural-based treatments for mixed urinary incontinence are lacking.<h4>Objective</h4>To determine whether intradetrusor onabotulinumtoxinA is more effective than midurethral sling for the treatment of mixed urinary incontinence in females.<h4>Design, setting, and participants</h4>Randomized, superiority trial involving females (aged ≥21 years) with moderate to severe bother from both stress and urgency urinary incontinence who had unsuccessful conservative treatments and oral medications. The study was conducted at 7 US sites with enrollment between July 2020 and September 2022; the last date of f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-05T11:44:37.481Z","creation":"2026-05-16T03:13:16.009Z"},"accession":"S-EPMC12053799","cross_references":{"pubmed":["40323617"],"doi":["10.1001/jama.2025.4682"]}}