biostudies-literatureLi MMinistry of EducationNIA NIH HHSNHLBI NIH HHSGrant-in-aid for Scientific ResearchMinistry of Education, Culture, Sports, Science, and Technology of JapanNIHNIGMS NIH HHSNIH HHS273-279https://www.ebi.ac.uk/biostudies/studies/S-EPMC12054729biostudies-literatureUnknown26(2)<h4>Aims</h4>Continued low mortality from coronary heart disease in Japan, despite deleterious changes in traditional risk factors, remains unexplained. Since aortic calcification (AC) was an early predictor of cardiovascular mortality, we compared the progression and incidence of AC between Japanese in Japan, white Americans, and third-generation Japanese Americans in the ERA JUMP cohort. We examined whether higher blood levels of marine-derived n-3 fatty acids (FAs) in Japanese than in Americans accounted for the difference.<h4>Methods and results</h4>Men (n = 700) aged 40-49 years (252 Japanese in Japan, 238 white, and 210 Japanese Americans) were examined at baseline and 4-7 years later. AC was evaluated from the aortic arch to the iliac bifurcation with computed tomography and quantifEuropean heart journal. Cardiovascular ImagingProgression of aortic calcification among Japanese in Japan and white and Japanese Americans: a prospective cohort study.PMC1205472923590790R01 AG038707N01-AG-4-2149R01 AG027060U01 AG0193492359079121790579U01-AG019349R01 HL071561N01-HC-05102P20-GM125526N01 HC005102P20 GM125526R01-HL068200R01-HL07156124790616R01-AG027060R01-AG038707R01 HL068200252530462324903621590688Miura KEdmundowicz DLi JKadota ASeto TWillcox BJKadowaki TKadowaki SChang YLi MOkamura TUeshima HSekikawa AEvans RMasaki KHFujiyoshi AfalseProgression of aortic calcification among Japanese in Japan and white and Japanese Americans: a prospective cohort study.<h4>Aims</h4>Continued low mortality from coronary heart disease in Japan, despite deleterious changes in traditional risk factors, remains unexplained. Since aortic calcification (AC) was an early predictor of cardiovascular mortality, we compared the progression and incidence of AC between Japanese in Japan, white Americans, and third-generation Japanese Americans in the ERA JUMP cohort. We examined whether higher blood levels of marine-derived n-3 fatty acids (FAs) in Japanese than in Americans accounted for the difference.<h4>Methods and results</h4>Men (n = 700) aged 40-49 years (252 Japanese in Japan, 238 white, and 210 Japanese Americans) were examined at baseline and 4-7 years later. AC was evaluated from the aortic arch to the iliac bifurcation with computed tomography and quantif2025-01-01T00:00:00Z2025 Jan2026-06-04T13:59:23.229Z2026-05-10T03:11:46.045ZS-EPMC120547293943733110.1093/ehjci/jeae270